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Comment
. 2022 Aug;32(8):705-706.
doi: 10.1038/s41422-022-00686-y.

Towards capturing of totipotency

Cuiqing Zhong #  1 , Ronghui Li #  2 , Juan Carlos Izpisua Belmonte  3
Affiliations
Comment

Towards capturing of totipotency

Cuiqing Zhong et al. Cell Res. 2022 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1. Summary of derivation of totipotent-like stem cells (TPS cells) and the characterization and evaluation of totipotency in vitro and in vivo.
TPS cells can be directly derived from 2-cell embryos under CPEC condition, and stably cultured in vitro for many passages. The molecular features of TPS cells were examined by multi-omics sequencing (upper). To functionally evaluate the differentiation potential of TPS cells, TPS-blastoid formation was performed in vitro and the transcriptome was analyzed by single-cell RNA-seq (middle). Further, in vivo contribution of TPS cells to embryonic and extraembryonic lineages was analyzed by chimerism (lower). Em, embryonic; ExEm, extraembryonic.
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