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. 2022 Jul:96:107340.
doi: 10.1016/j.ijscr.2022.107340. Epub 2022 Jun 22.

Primary intra-testicular rhabdomyosarcoma: Case report

Elouarith Ihssan  1 , Elmajoudi Salma  2 , Mamad Ayoub  3 , Slaoui Amine  3 , Bernoussi Zakia  2 , Znati Kaoutar  2
Affiliations

Primary intra-testicular rhabdomyosarcoma: Case report

Elouarith Ihssan et al. Int J Surg Case Rep. 2022 Jul.

Abstract
in English, French

  1. •

    Intra-testicular localization of rhabdomyosarcoma remains exceptional and few cases have been reported in the literature.

  2. •

    Anatomopathological examination is the gold standard for diagnosis and for confirming the intratesticular origin

  3. •

    Radical inguinal orchiectomy followed by chemotherapy is the treatment of choice.

Introduction: RMS is a highly aggressive neoplasm that represents the most common soft tissue sarcoma in children and adolescents. It occurs most frequently in the head, neck, and genitourinary tract. Intra-testicular localization remains exceptional and very few cases have been reported in the literature.

Case presentation: We represent a case of a 16-year-old patient, with no medical and surgical history, who presented with a painless right scrotal mass. Imaging revealed a suspicious testicular mass with no other secondary location. The patient underwent a right inguinal orchidectomy and the anatomopathological study confirmed the diagnosis of intratesticular rhabdomyosarcoma. The patient subsequently was referred to the oncology department for chemotherapy (Agha et al., 2020).

Discussion: Intra-testicular rhabdomyosarcoma is a very rare malignant mesenchymal tumor showing skeletal muscle differentiation. They are subclassified into four major histological subtypes: Embryonal, alveolar, pleomorphic and Spindle cell/sclerosing rhabdomyosarcoma. ERMS is the most common subtype. Diagnosis of ITRMS is based on anatomopathological examination. Surgery and chemotherapy remain the mainstay of treatment. Radiotherapy is useful for local recurrence and metastasis.

Conclusion: In this report we aim to describe the clinical, pathological and immunohistochemical features of this rare entity, and to highlight the importance of an early diagnosis followed by treatment combining Radical inguinal orchiectomy and chemotherapy and its role in improving prognosis.

Keywords: Intra testicular tumor; Pathology; Rhabdomyosarcoma.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
A thoracic-abdominopelvic CT scan showing at the pelvic level a right scrotal mass.
Fig. 2
Fig. 2
Cut section of the resected specimen.
Fig. 3
Fig. 3
ERMS. A: Microscopic image showing mesenchymal profilation with alternating areas of loose and dense cellularity (HE ×40). B: Rare cells suggest skeletal muscle differentiation (HE ×400) C: tumor cells show diffuse nuclear myogenin staining (×200). D: and positive AML staining (×100).
See this image and copyright information in PMC

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