Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Jul 5;34(7):942-944.
doi: 10.1016/j.cmet.2022.06.006.

Diabesity? No worries, FKBP11 to the rescue

Michael Karin  1
Affiliations
Free article
Comment

Diabesity? No worries, FKBP11 to the rescue

Michael Karin. Cell Metab. .
Free article

Abstract

Obesity-induced type 2 diabetes, or diabesity, is associated with ER stress, UPR activation, and insulin resistance through poorly understood mechanisms. Herrema et al. (2022) report that the XBP1 target FKBP11 is repressed in the obese mouse liver and that its re-expression activates a protective UPR pathway that restores insulin sensitivity.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests M.K. is a founder of Elgia Pharmaceuticals and received research support from Gossamer Bio, Jansen Pharmaceuticals, and Merck.

Comment on

Publication types

Substances

LinkOut - more resources