Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
- PMID: 35793962
- PMCID: PMC9970809
- DOI: 10.2169/internalmedicine.9580-22
Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
Abstract
We herein report a rare case of spinal cord compression due to epidural involvement of acute myeloid leukemia (AML). A 14-year-old boy presented with a 7-day history of back pain, paraplegia and hypoesthesia. Contrast-enhanced computed tomography revealed an epidural mass. Emergency laminectomy and resection of the mass were performed. Histopathologically, the resected mass was comparable to an extramedullary mass of AML. Chemotherapy was initiated, and complete remission was achieved. Neurological sequelae remained after the treatment. Based on the present and previous reports, spinal cord compression from epidural AML involvement may progress rapidly.
Keywords: acute myeloid leukemia; extramedullary infiltration; spinal cord compression.
Conflict of interest statement
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References
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- Stove HK, Sandahl JD, Abrahamsson J, et al. Extrameddullary leukemia in children with acute myeloid leukemia: a population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO). Pediatr Blood Cancer 64: e26520, 2017. - PubMed
-
- Prased D, Schiff D. Malignant spinal-cord compression. Lancet Oncol 6: 15-24, 2005. - PubMed
-
- Gunes D, Uysal KM, Cetinlkaya H, et al. Paravertebral malignant tumors of childhood: analysis of 28 pediatric patients. Childs Nerv Syst 25: 63-69, 2009. - PubMed
