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. 2022 Jul 6;12(1):11422.
doi: 10.1038/s41598-022-15425-x.

Early retinal functional alteration in relation to diabetes duration in patients with type 2 diabetes without diabetic retinopathy

Sangeetha Srinivasan  1 , Sobha Sivaprasad  2 , Ramachandran Rajalakshmi  3 , Ranjit Mohan Anjana  3 , Rayaz A Malik  4   5 , Vaitheeswaran Kulothungan  6 , Viswanathan Natarajan  7 , Rajiv Raman  8 , Muna Bhende  8
Affiliations

Early retinal functional alteration in relation to diabetes duration in patients with type 2 diabetes without diabetic retinopathy

Sangeetha Srinivasan et al. Sci Rep. .

Abstract

To examine the retinal structure and function in relation to diabetes duration and glycemia in patients without diabetic retinopathy (DR). 85 adults with type 2 diabetes without DR or macular edema underwent dilated indirect ophthalmoscopy, optical coherence tomography (OCT), ultra-wide field fundus photography, multifocal electroretinography (mfERG) and HbA1C assessment. Patients were stratified as those with diabetes duration < 10 years and ≥ 10 years. Right eyes of all participants were analyzed. mfERG was analysed as ring 12, 34, 56. No significant differences were noted in OCT-derived retinal thickness measures between groups. mfERG P1 latencies were delayed, and amplitudes (nV/deg2) were reduced in all three rings in those with diabetes duration ≥ 10 years vs. < 10 years, with significant correlations to diabetes duration in all rings. Logistic regression showed that duration of diabetes ≥ 10 years was associated with greater age (odds ratio (OR) 1.081, 95% CI 1.022, 1.143) and lower P1 amplitudes in the middle ring (OR 0.924, 95% CI 0.854, 0.999). No significant correlations were observed between HbA1c and retinal measures. In the absence of DR, early retinal functional alterations are detectable on mfERG in patients with longer diabetes duration, but with no difference in OCT-derived retinal thickness.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Grouping of mfERG rings as inner ring (rings 12), middle ring (ring 34) and outer ring (ring 56) as described by Seiple et al..
See this image and copyright information in PMC

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