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Review
. 2023;21(8):1646-1665.
doi: 10.2174/1570159X20666220706102708.

Epilepsy and Cognitive Impairment in Childhood and Adolescence: A Mini-Review

Francesca Felicia Operto  1 , Grazia Maria Giovanna Pastorino  1 , Andrea Viggiano  2 , Giovanni Battista Dell'Isola  3 , Gianluca Dini  3 , Alberto Verrotti  3 , Giangennaro Coppola  1
Affiliations
Review

Epilepsy and Cognitive Impairment in Childhood and Adolescence: A Mini-Review

Francesca Felicia Operto et al. Curr Neuropharmacol. 2023.

Abstract

Managing epilepsy in people with an intellectual disability remains a therapeutic challenge and must take into account additional issues such as diagnostic difficulties and frequent drug resistance. Advances in genomic technologies improved our understanding of epilepsy and raised the possibility to develop patients-tailored treatments acting on the key molecular mechanisms involved in the development of the disease. In addition to conventional antiseizure medications (ASMs), ketogenic diet, hormone therapy and epilepsy surgery play an important role, especially in cases of drugresistance. This review aims to provide a comprehensive overview of the mainfactors influencing cognition in children and adolescents with epilepsy and the main therapeutic options available for the epilepsies associated with intellectual disability.

Keywords: Epilepsy; anti-seizure medication; cognitive impairment; ganaxolone; gene therapy; intellectual disability; ketogenic diet.

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Conflict of interest statement

The authors declare they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. (1)
Fig. (1)
Multiple factors and their interaction that impact on cognitive function of children and adolescents with epilepsy.
See this image and copyright information in PMC

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