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. 2022 Jun 20:13:922677.
doi: 10.3389/fneur.2022.922677. eCollection 2022.

Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Hong-Yu Lin  1 , Qing-Qing Wei  1 , Jian-Yi Huang  1 , Xing-Hua Pan  1 , Ning-Chao Liang  1 , Cai-Xia Huang  1 , Teng Long  1 , Wen Gao  2 , Sheng-Liang Shi  3
Affiliations

Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Hong-Yu Lin et al. Front Neurol. .

Abstract

Background: The relationship between mortality and seizures after intracerebral hemorrhage (ICH) has not yet been understood until now. A meta-analysis was performed to assess the effect of post-ICH seizures on mortality among patients with ICH.

Methods: PubMed and Embase were searched from the establishment of the databases to December 2021 to identify literature that evaluated the relationship between post-ICH seizures and mortality in ICH. Crude odds ratios and adjusted odds ratios with a 95% confidence interval (CI) were pooled using a random-effects model.

Results: Thirteen studies involving 245,908 participants were eventually included for analysis. The pooled estimate suggested that post-ICH seizures were not associated with significantly increased mortality in patients with ICH (crude odds ratios 1.35, 95% CI: 0.91-2; adjusted adds ratios 1.22, 95% CI: 0.78-1.88). However, the relationship was not consistent in subgroup analysis or robust in a sensitivity analysis.

Conclusions: This meta-analysis proved that post-ICH seizures were not associated with significantly increased mortality in patients with ICH. However, this result could be influenced by confounding factors, so more high-quality research is needed.

Keywords: intracerebral hemorrhage; meta-analysis; mortality; outcome; seizures; systematic review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of screening for the systematic review and meta-analysis.
Figure 2
Figure 2
Forest plot of crude odds ratio on the relationship between mortality and seizures after intracerebral hemorrhage.
Figure 3
Figure 3
Funnel plot for publication bias of the relationship between mortality and seizures after intracerebral hemorrhage.
Figure 4
Figure 4
Forest plot of the adjusted odds ratio on the relationship between mortality and seizures after intracerebral hemorrhage.
See this image and copyright information in PMC

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