Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 20:13:922677.
doi: 10.3389/fneur.2022.922677. eCollection 2022.

Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Hong-Yu Lin  1 , Qing-Qing Wei  1 , Jian-Yi Huang  1 , Xing-Hua Pan  1 , Ning-Chao Liang  1 , Cai-Xia Huang  1 , Teng Long  1 , Wen Gao  2 , Sheng-Liang Shi  3
Affiliations

Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Hong-Yu Lin et al. Front Neurol. .

Abstract

Background: The relationship between mortality and seizures after intracerebral hemorrhage (ICH) has not yet been understood until now. A meta-analysis was performed to assess the effect of post-ICH seizures on mortality among patients with ICH.

Methods: PubMed and Embase were searched from the establishment of the databases to December 2021 to identify literature that evaluated the relationship between post-ICH seizures and mortality in ICH. Crude odds ratios and adjusted odds ratios with a 95% confidence interval (CI) were pooled using a random-effects model.

Results: Thirteen studies involving 245,908 participants were eventually included for analysis. The pooled estimate suggested that post-ICH seizures were not associated with significantly increased mortality in patients with ICH (crude odds ratios 1.35, 95% CI: 0.91-2; adjusted adds ratios 1.22, 95% CI: 0.78-1.88). However, the relationship was not consistent in subgroup analysis or robust in a sensitivity analysis.

Conclusions: This meta-analysis proved that post-ICH seizures were not associated with significantly increased mortality in patients with ICH. However, this result could be influenced by confounding factors, so more high-quality research is needed.

Keywords: intracerebral hemorrhage; meta-analysis; mortality; outcome; seizures; systematic review.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of screening for the systematic review and meta-analysis.
Figure 2
Figure 2
Forest plot of crude odds ratio on the relationship between mortality and seizures after intracerebral hemorrhage.
Figure 3
Figure 3
Funnel plot for publication bias of the relationship between mortality and seizures after intracerebral hemorrhage.
Figure 4
Figure 4
Forest plot of the adjusted odds ratio on the relationship between mortality and seizures after intracerebral hemorrhage.
See this image and copyright information in PMC

References

    1. Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. (2009) 8:355–69. 10.1016/S1474-4422(09)70025-0 - DOI - PubMed
    1. Van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A, Klijn CJ. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. (2010) 9:167–76. 10.1016/S1474-4422(09)70340-0 - DOI - PubMed
    1. Balami JS, Buchan AM. Complications of intracerebral haemorrhage. Lancet Neurol. (2012) 11:101–18. 10.1016/S1474-4422(11)70264-2 - DOI - PubMed
    1. Kilpatrick CJ, Davis SM, Tress BM, Rossiter SC, Hopper JL, Vandendriesen ML. Epileptic seizures in acute stroke. Arch Neurol. (1990) 47:157–60. 10.1001/archneur.1990.00530020053014 - DOI - PubMed
    1. Szaflarski JP, Rackley AY, Kleindorfer DO, Khoury J, Woo D, Miller R, et al. Incidence of seizures in the acute phase of stroke: a population-based study. Epilepsia. (2008) 49:974–81. 10.1111/j.1528-1167.2007.01513.x - DOI - PMC - PubMed

Publication types

LinkOut - more resources