Ready for regulatory use: NAMs and NGRA for chemical safety assurance

Abstract

New approach methodologies (NAMs) that do not use experimental animals are, in certain settings, entirely appropriate for assuring the safety of chemical ingredients, although regulatory adoption has been slow. In this opinion article we discuss how scientific advances that utilize NAMs to certify systemic safety are available now and merit broader acceptance within the framework of next generation risk assessments (NGRA).

Keywords: chemical safety; new approach methodologies (NAMs); next generation risk assessement (NGRA); non-animal approaches.