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Review
. 2022 Nov;24(11):1401-1412.
doi: 10.1007/s11912-022-01311-2. Epub 2022 Jul 7.

Do Cancer and Cancer Treatments Accelerate Aging?

Roma Bhatia  1 , Shernan Holtan  2 , Najla El Jurdi  2 , Anna Prizment  2 , Anne Blaes  3
Affiliations
Review

Do Cancer and Cancer Treatments Accelerate Aging?

Roma Bhatia et al. Curr Oncol Rep. 2022 Nov.

Abstract

Purpose of review: This review focuses on describing the mechanisms and clinical manifestations that underlie accelerated aging associated with cancer and its treatment.

Recent findings: The direct and indirect effects of cancer and its treatment are associated with late occurrence of comorbidities that happen earlier or more frequently in cancer survivors compared to cancer-free individuals, otherwise known as accelerated aging. Use of senolytics and dietary and exercise interventions including prehabilitation, caloric restriction, and rehabilitation are currently under investigation to reverse or decelerate the aging process and will be covered in this review. Further research on how to decelerate or reverse aging changes associated with cancer and its treatment will be of paramount importance as the number of cancer survivors continues to grow.

Keywords: Aging; Cancer; Nutrition.

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Conflict of interest statement

Roma Bhatia declares that she has no conflict of interest. Shernan Holtan has received Research Funding from Incyte Corporation and VITRAC Therapeutics; has received clinical trial adjudication fees from CSL Behring; and has received compensation for service on scientific advisory boards from Generon and Ossium Health. Najla El Jurdi declares that she has no conflict of interest. Anna Prizment declares that she has no conflict of interest. Anne Blaes declares that she has no conflict of interest.

Figures

Fig. 1
Fig. 1
Normal aging versus accelerated aging
See this image and copyright information in PMC

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