Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022:2533:217-228.
doi: 10.1007/978-1-0716-2501-9_13.

Translation Phases in Eukaryotes

Sandra Blanchet  1 , Namit Ranjan  2
Affiliations
Review

Translation Phases in Eukaryotes

Sandra Blanchet et al. Methods Mol Biol. 2022.

Abstract

Protein synthesis in eukaryotes is carried out by 80S ribosomes with the help of many specific translation factors. Translation comprises four major steps: initiation, elongation, termination, and ribosome recycling. In this review, we provide a comprehensive list of translation factors required for protein synthesis in yeast and higher eukaryotes and summarize the mechanisms of each individual phase of eukaryotic translation.

Keywords: Ribosome; Translation; Yeast; mRNA; tRNA.

PubMed Disclaimer

References

    1. Dever TE, Green R (2012) The elongation, termination, and recycling phases of translation in eukaryotes. Cold Spring Harb Perspect Biol 4:a013706 - PMC - PubMed
    1. Schuller AP, Wu CC, Dever TE, Buskirk AR, Green R (2017) eIF5A functions globally in translation elongation and termination. Mol Cell 66:194–205 e5 - PMC - PubMed
    1. Hinnebusch AG, Lorsch JR (2012) The mechanism of eukaryotic translation initiation: new insights and challenges. Cold Spring Harb Perspect Biol 4:a011544 - PMC - PubMed
    1. Jackson RJ, Hellen CU, Pestova TV (2010) The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 11:113–127 - PMC - PubMed
    1. Siridechadilok B, Fraser CS, Hall RJ, Doudna JA, Nogales E (2005) Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science 310:1513–1515 - PubMed

Publication types

MeSH terms

LinkOut - more resources