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Review
. 2023 Jan 6;76(1):89-95.
doi: 10.1093/cid/ciac550.

Listeria monocytogenes Illness and Deaths Associated With Ongoing Contamination of a Multiregional Brand of Ice Cream Products, United States, 2010-2015

Amanda R Conrad  1   2 , Sheri Tubach  3 , Venessa Cantu  4 , Lindsey Martin Webb  3 , Steven Stroika  2 , Steve Moris  5 , Megan Davis  6 , D Charles Hunt  3 , Kristy K Bradley  7 , Zuzana Kucerova  2 , Errol Strain  8 , Matthew Doyle  8 , Angela Fields  8 , Karen P Neil  2 , L Hannah Gould  2 , Kelly A Jackson  2 , Matthew E Wise  2 , Patricia M Griffin  2 , Brendan R Jackson  2
Affiliations
Review

Listeria monocytogenes Illness and Deaths Associated With Ongoing Contamination of a Multiregional Brand of Ice Cream Products, United States, 2010-2015

Amanda R Conrad et al. Clin Infect Dis. .

Abstract

Background: Frozen foods have rarely been linked to Listeria monocytogenes illness. We describe an outbreak investigation prompted by both hospital clustering of illnesses and product testing.

Methods: We identified outbreak-associated listeriosis cases using whole-genome sequencing (WGS), product testing results, and epidemiologic linkage to cases in the same Kansas hospital. We reviewed hospital medical and dietary records, product invoices, and molecular subtyping results. Federal and state officials tested product and environmental samples for L. monocytogenes.

Results: Kansas officials were investigating 5 cases of listeriosis at a single hospital when, simultaneously, unrelated sampling for a study in South Carolina identified L. monocytogenes in Company A ice cream products made in Texas. Isolates from 4 patients and Company A products were closely related by WGS, and the 4 patients with known exposures had consumed milkshakes made with Company A ice cream while hospitalized. Further testing identified L. monocytogenes in ice cream produced in a second Company A production facility in Oklahoma; these isolates were closely related by WGS to those from 5 patients in 3 other states. These 10 illnesses, involving 3 deaths, occurred from 2010 through 2015. Company A ultimately recalled all products.

Conclusions: In this US outbreak of listeriosis linked to a widely distributed brand of ice cream, WGS and product sampling helped link cases spanning 5 years to 2 production facilities, indicating longstanding contamination. Comprehensive sanitation controls and environmental and product testing for L. monocytogenes with regulatory oversight should be implemented for ice cream production.

Keywords: food safety; ice cream; listeriosis; whole-genome sequencing.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Minimum spanning tree representing the whole-genome multilocus sequence typing results of Listeria monocytogenes isolates from patients, ice cream products, and manufacturing facilities—United States, January 2010–April 2015. Abbreviation: AD, allele difference.
Figure 2.
Figure 2.
Persons infected with an outbreak strain of Listeria monocytogenes by month of illness onset—United States, January 2010–January 2015 (N = 10).
See this image and copyright information in PMC

Comment in

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