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Review
. 2022 Aug;37(4):587-598.
doi: 10.3803/EnM.2022.1528. Epub 2022 Jul 8.

Long-Term Outcomes of Congenital Adrenal Hyperplasia

Anna Nordenström  1   2 , Svetlana Lajic  1   2 , Henrik Falhammar  3   4
Affiliations
Review

Long-Term Outcomes of Congenital Adrenal Hyperplasia

Anna Nordenström et al. Endocrinol Metab (Seoul). 2022 Aug.

Abstract

A plethora of negative long-term outcomes have been associated with congenital adrenal hyperplasia (CAH). The causes are multiple and involve supra-physiological gluco- and mineralocorticoid replacement, excess adrenal androgens both intrauterine and postnatal, elevated steroid precursor and adrenocorticotropic hormone levels, living with a congenital condition as well as the proximity of the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene to other genes. This review aims to discuss the different long-term outcomes of CAH.

Keywords: Bone fracture; Cardiovascular diseases; Fertility; Mental disorders; Mortality; Neoplasms.

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Conflict of interest statement

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
A 18×15×9.5 cm large left-sided and a 2.5×2 cm large right-sided myelolipoma was found in a man in his 40s with simple virilizing congenital adrenal hyperplasia. The hormonal control had been poor for years.
See this image and copyright information in PMC

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