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Review
. 2022 Aug;37(4):587-598.
doi: 10.3803/EnM.2022.1528. Epub 2022 Jul 8.

Long-Term Outcomes of Congenital Adrenal Hyperplasia

Anna Nordenström  1   2 , Svetlana Lajic  1   2 , Henrik Falhammar  3   4
Affiliations
Review

Long-Term Outcomes of Congenital Adrenal Hyperplasia

Anna Nordenström et al. Endocrinol Metab (Seoul). 2022 Aug.

Abstract

A plethora of negative long-term outcomes have been associated with congenital adrenal hyperplasia (CAH). The causes are multiple and involve supra-physiological gluco- and mineralocorticoid replacement, excess adrenal androgens both intrauterine and postnatal, elevated steroid precursor and adrenocorticotropic hormone levels, living with a congenital condition as well as the proximity of the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene to other genes. This review aims to discuss the different long-term outcomes of CAH.

Keywords: Bone fracture; Cardiovascular diseases; Fertility; Mental disorders; Mortality; Neoplasms.

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Conflict of interest statement

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
A 18×15×9.5 cm large left-sided and a 2.5×2 cm large right-sided myelolipoma was found in a man in his 40s with simple virilizing congenital adrenal hyperplasia. The hormonal control had been poor for years.
See this image and copyright information in PMC

References

    1. Gidlof S, Falhammar H, Thilen A, von Dobeln U, Ritzen M, Wedell A, et al. One hundred years of congenital adrenal hyperplasia in Sweden: a retrospective, population-based cohort study. Lancet Diabetes Endocrinol. 2013;1:35–42. - PubMed
    1. Arlt W, Willis DS, Wild SH, Krone N, Doherty EJ, Hahner S, et al. Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients. J Clin Endocrinol Metab. 2010;95:5110–21. - PMC - PubMed
    1. Claahsen-van der Grinten HL, Speiser PW, Ahmed SF, Arlt W, Auchus RJ, Falhammar H, et al. Congenital adrenal hyperplasia: current insights in pathophysiology, diagnostics, and management. Endocr Rev. 2022;43:91–159. - PMC - PubMed
    1. Kocova M, Concolino P, Falhammar H. Characteristics of In2G variant in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Front Endocrinol (Lausanne) 2022;12:788812. - PMC - PubMed
    1. Merke DP, Auchus RJ. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency. N Engl J Med. 2020;383:1248–61. - PubMed

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