Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan;18(1):115-116.
doi: 10.4103/1673-5374.340410.

Brain network modulation in Alzheimer's disease: clinical phenotypes and windows of opportunity

Affiliations

Brain network modulation in Alzheimer's disease: clinical phenotypes and windows of opportunity

Lorenzo Pini. Neural Regen Res. 2023 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Functional connectivity can help to guide the selection of the most appropriate parameters for non-invasive brain stimulation protocol based on spatial and temporal patterns. Different spatial brain networks are linked with different Alzheimer’s disease clinical phenotypes. Similarly, different time windows, recapitulating the distribution of molecular abnormalities (amyloid-beta (Aβ) and tau accumulation), can exhibit specific functional connectivity abnormalities (hyper-connectivity versus hypo-connectivity).

References

    1. Doelling KB, Assaneo MF. Neural oscillations are a start toward understanding brain activity rather than the end. PLoS Biol. 2021;19:e3001234. - PMC - PubMed
    1. Fox MD. Mapping symptoms to brain networks with the human connectome. N Engl J Med. 2018;379:2237–2245. - PubMed
    1. Graff-Radford J, Yong KXX, Apostolova LG, Bouwman FH, Carrillo M, Dickerson BC, Rabinovici GD, Schott JM, Jones DT, Murray ME. New insights into atypical Alzheimer's disease in the era of biomarkers. Lancet Neurol. 2021;20:222–234. - PMC - PubMed
    1. Musiek ES, Bennett DA. Aducanumab and the “post-amyloid”era of Alzheimer research? Neuron. 2021;109:3045–3047. - PMC - PubMed
    1. Pezzulo G, Zorzi M, Corbetta M. The secret life of predictive brains:what's spontaneous activity for? Trends Cogn Sci. 2021;25:730–743. - PMC - PubMed