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. 2023 Jan;18(1):125-126.
doi: 10.4103/1673-5374.343895.

The intricate debate on neurodegeneration and neuroinflammation in Parkinson's disease: which came first?

Antonella Cardinale  1 , Valeria Calabrese  2
Affiliations

The intricate debate on neurodegeneration and neuroinflammation in Parkinson's disease: which came first?

Antonella Cardinale et al. Neural Regen Res. 2023 Jan.
No abstract available

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Figures

Figure 1
Figure 1
The inflammatory mechanism induced by alpha-synuclein accumulation. Formation of toxic α-synuclein in Parkinson’s disease (PD), specifically at the presynaptic terminal, leads to changes of proteins involved in synaptic transmission (i.e., SNARE complex alteration and increased glutamate release), determining synaptic dysfunction and contributing to degeneration of dopaminergic neurons. Moreover, α-synuclein aggregation could be considered as a causal link between neurodegeneration and neuroinflammation in PD, inducing astrocyte and microglia reaction, consequent release of cytokines and activation of adaptive immune system. SNARE: Soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor.
See this image and copyright information in PMC

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