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. 2022 Jun 28:2022:8586943.
doi: 10.1155/2022/8586943. eCollection 2022.

Imaging Diagnosis of Primary Liver Cancer Using Magnetic Resonance Dilated Weighted Imaging and the Treatment Effect of Sorafenib

Bin Fan  1 , Yunyi Zhang  2 , Shuai Guo  3
Affiliations

Imaging Diagnosis of Primary Liver Cancer Using Magnetic Resonance Dilated Weighted Imaging and the Treatment Effect of Sorafenib

Bin Fan et al. Comput Math Methods Med. .

Abstract

Objective: This work explores the application value of dilated weighted imaging (DWI) in the diagnosis of primary liver cancer (PLC) and the effect of sorafenib in the treatment of PLC.

Methods: 88 patients with PLC who were treated in The First Affiliated Hospital of Northwest University from March 2019 to March 2021 were selected and randomly rolled into an experimental group and a control group, with 44 cases in each group. Patients in both groups were treated with transcatheter arterial chemoembolization (TACE), and the patients in the experimental group were treated with oral sorafenib on the basis of TACE. The indicators of complications, short-term efficacy (STE), and long-term efficacy (LTE) of the two groups were observed. All patients received DWI and magnetic resonance (MR) plain scan. The diagnostic accuracy and misdiagnosis rate of the two methods in diagnosing the PLC were compared.

Results: The accuracy, specificity, and sensitivity of MR plain scan were 68%, 88%, and 89%, respectively, while those of DWI were 96%, 95%, and 94.2%, respectively. It indicated that the accuracy, specificity, and sensitivity of DWI in diagnosing lesions were better than those of MR plain scan, especially the diagnostic accuracy (P < 0.05). The objective response rate (ORR) and disease control rate (DCR) of the STE in the experimental group were 30% and 97%, respectively, and those in the control group were 6% and 54.5%, respectively. The experimental group's mean progression-free survival (mPFS) and mean overall survival (mOS) were 12 and 25 months, respectively, while the control group's were 8 and 19 months, respectively. It was concluded that the mPFS and mOS of patients receiving TACE combined with oral sorafenib were much higher than those receiving TACE only (P < 0.05).

Conclusion: DWI and TACE combined with sorafenib had high application value in the diagnosis and treatment of PLC.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Imaging images of typical cases.
Figure 2
Figure 2
Display of correct diagnosis results of lesions. Note: ∗ and # suggested P < 0.05 compared with the standard value and the MR plain scan, respectively.
Figure 3
Figure 3
The misdiagnosis of lesions of two methods. Note: ∗ meant P < 0.05 in contrast to DWI.
Figure 4
Figure 4
The number of patients in each stage of the two groups of patients. Note: ∗ meant P < 0.05 compared with the control group.
Figure 5
Figure 5
Comparison of ORR and DCR of patients. Note: ∗ meant P < 0.05 compared with the control group.
Figure 6
Figure 6
Survival rates of patients in the two groups at different time periods. Note: ∗ meant P < 0.05 compared with the control group.
Figure 7
Figure 7
Comparison of mPFS and mOS of patients. Note: ∗ meant P < 0.05 compared with the control group.
Figure 8
Figure 8
Comparison of AFP of patients. Note: # and ∗ meant P < 0.05 in contrast to the control group and the value before treatment, respectively.
Figure 9
Figure 9
Complications of the two groups of patients: (a) number of people; (b) proportion.
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