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Case Reports
. 2022 Jun 3:25:93-96.
doi: 10.1016/j.jdcr.2022.05.027. eCollection 2022 Jul.

Generalized indeterminate cell histiocytosis successfully treated with methotrexate

Erina Lie  1 , Jaroslaw Jedrych  1 , Ronald Sweren  1 , Michelle L Kerns  1
Affiliations
Case Reports

Generalized indeterminate cell histiocytosis successfully treated with methotrexate

Erina Lie et al. JAAD Case Rep. .
No abstract available

Keywords: ICH, indeterminate cell histiocytosis; LCH, Langerhans cell histiocytosis; Langerhans cell histiocytosis; PUVA, psoralen and ultraviolet A; indeterminate cell histiocytosis; methotrexate; non-Langerhans cells histiocytosis; papulonodules; skin diseases.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Disseminated erythematous dome-shaped firm papules on the chest (A) and back (B).
Fig 2
Fig 2
A punch biopsy of the left part of the chest. Dermal infiltrates composed of crowded histiocytoid cells, lymphocytes, plasma cells, and rare eosinophils were observed (A and B, Hematoxylin-eosin stain; original magnifications: A, ×40; B, ×400.)
Fig 3
Fig 3
Immunohistochemical stain of punch biopsy specimen of the left part of the chest. A, CD1a diffusely positive in dermal histiocytoid cells and epidermal Langerhans cells. B, S100 diffusely positive in dermal histiocytoid cells and epidermal Langerhans cells. C, CD207 (Langerin) negative in dermal infiltrate and positive in epidermal Langerhans cells. (A, CD1a stain; original magnification, ×40; B, S100 stain; original magnification, ×40; C, CD207 stain; original magnification, ×40)
Fig 4
Fig 4
Six months after treatment with low-dose methotrexate, diffuse flattening of the papules on the face (A), chest (B), and back (C, D) were observed.
See this image and copyright information in PMC

References

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