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. 2022 Jun 15;13(6):422-433.
doi: 10.4239/wjd.v13.i6.422.

Impact of stopping smoking on metabolic parameters in diabetes mellitus: A scoping review

Magdalena Walicka  1 , Cristina Russo  2 , Michael Baxter  2 , Isaac John  2 , Grazia Caci  3 , Riccardo Polosa  4
Affiliations

Impact of stopping smoking on metabolic parameters in diabetes mellitus: A scoping review

Magdalena Walicka et al. World J Diabetes. .

Abstract

The purpose of this scoping review is to create a single narrative that describes the impact of smoking cessation on metabolic parameters in people with diabetes. It is generally well accepted that smoking enhances the harmful effects of elevated blood glucose levels, accelerating the vascular damage seen in patients with diabetes. Smoking cessation has clear benefits in terms of reducing cardiovascular morbidity and mortality. However, there is less evidence for the impact of smoking cessation on other diabetes-related complications. Studies in people with diabetes have shown improvement as well as temporary deterioration in glycemic control after ceasing smoking. Only a few studies have described the effect of quitting smoking on insulin resistance and lipid parameters, however, their results have been inconclusive. In this situation, healthcare professionals should not assume that cessation of smoking will improve metabolic parameters in patients with diabetes. It seems they should, first of all, emphasize the prevention of weight gain that may be associated with quitting smoking. The lack of data regarding the metabolic effects of smoking and smoking cessation in diabetes is very disappointing and this area needs to be addressed.

Keywords: Diabetes; Glucose; Insulin resistance; Lipids; Smoking; Smoking cessation.

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Conflict of interest statement

Conflict-of-interest statement: RP is full tenure professor of Internal Medicine at the University of Catania (Italy). RP has received lecture fees and research funding from Pfizer, GlaxoSmithKline, CV Therapeutics, NeuroSearch A/S, Sandoz, MSD, Boehringer Ingelheim, Novartis, Duska Therapeutics, and Forest Laboratories. RP has also received grants from European Commission initiatives (U-BIOPRED and AIRPROM) and from the Integral Rheumatology & Immunology Specialists Network (IRIS) initiative. He has also served as a consultant for Pfizer, Global Health Alliance for treatment of tobacco dependence, CV Therapeutics, Boehringer Ingelheim, Novartis, Duska Therapeutics, ECITA (Electronic Cigarette Industry Trade Association, in the UK), Arbi Group Srl., Health Diplomats, and Sermo Inc. RP has served on the Scientific Advisory Board of Cordex Pharma, Inc., CV Therapeutics, Duska Therapeutics Inc, Pfizer, and PharmaCielo. RP is also founder of the Center for Tobacco prevention and treatment (CPCT) at the University of Catania and of the Center of Excellence for the acceleration of HArm Reduction (CoEHAR) at the same University, which has received support from FSFW to conduct 8 independent investigator-initiated research projects on harm reduction. RP has filed a patent application concerning an app tracker for smoking behaviour developed for ECLAT Srl. RP is involved in the following pro bono activities: scientific advisor for LIAF, Lega Italiana Anti Fumo (Italian acronym for Italian Anti-Smoking League), the Consumer Advocates for Smoke-free Alternatives (CASAA) and the International Network of Nicotine Consumers Organizations (INNCO); Chair of the European Technical Committee for standardization on “Requirements and test methods for emissions of electronic cigarettes” (CEN/TC 437; WG4). All other authors have no declared relevant conflict of interest to declare in relation to this study.

References

    1. World Health Organization. Newsroom. Tobacco. [cited 26 July 2021]. Available from: https://www.who.int/news-room/fact-sheets/detail/tobacco .
    1. GBD 2015 Tobacco Collaborators. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet. 2017;389:1885–1906. - PMC - PubMed
    1. Institute for Health Metrics and Evaluation. Findings from the Global Burden of Disease Study 2017. Seattle, WA: IHME, 2018. [cited 26 July 2021]. Available from: https://www.healthdata.org/sites/default/files/files/policy_report/2019/... .
    1. IHME Institute for Health Metrics and Evaluation FHM GBD Compare-Viz Hub. 2020. [cited 26 July 2021]. Available from: https://vizhub.healthdata.org/gbd-compare/
    1. Guarino F, Cantarella G, Caruso M, Russo C, Mancuso S, Arcidiacono G, Cacciola RR, Bernardini R, Polosa R. Endothelial activation and injury by cigarette smoke exposure. J Biol Regul Homeost Agents. 2011;25:259–268. - PubMed

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