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Review
. 2022 Jun 22:13:878407.
doi: 10.3389/fphar.2022.878407. eCollection 2022.

Evidence-Based Management of Uterine Fibroids With Botanical Drugs-A Review

Masita Arip  1 , Vi Lien Yap  2 , Mogana Rajagopal  2 , Malarvili Selvaraja  2 , K Dharmendra  3 , Sasikala Chinnapan  2
Affiliations
Review

Evidence-Based Management of Uterine Fibroids With Botanical Drugs-A Review

Masita Arip et al. Front Pharmacol. .

Abstract

Uterine fibroids (UFs) are a common benign gynecological tumor that affect the majority of women over their lifetime. Several pharmacological agents are available to reduce the size of fibroids and ameliorate the symptoms of UF. However, these drugs are expensive and are usually associated with profound side effects. Thus, botanical drugs are gaining attention in this era due to their cost effectiveness with a comparable and more potent therapeutic efficacy while demonstrating lesser adverse effects. The objective of this review is to summarize the available information on the mechanism of various botanical drugs and polyherbal formulations with anti-uterine fibroid activity. A systematic search was performed on botanical drugs with anti-uterine fibroid activity using several search engines, which include PubMed, Google Scholar, and Science Direct. Based on the literatures identified, a total of five botanical drugs and three polyherbal formulations were included and discussed in this review, which yields useful information regarding the mechanism of different botanical drugs and polyherbal formulations in exerting anti-uterine fibroid activity for its potential use as an alternative treatment choice for uterine fibroids.

Keywords: botanical drug; leiomyoma; management; mechanism; polyherbal; uterine fibroids.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic representation of a selection of articles.
FIGURE 2
FIGURE 2
Summarized anti-uterine fibroid mechanisms of various botanical drugs and polyherbal formulations. Adapted from (Islam et al., 2013).
FIGURE 3
FIGURE 3
Common anti-uterine fibroid mechanism between botanical drugs and polyherbal formulation.
See this image and copyright information in PMC

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