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Review
. 2022 Nov;77(11):3185-3198.
doi: 10.1111/all.15430. Epub 2022 Jul 15.

Role of dietary fiber in promoting immune health-An EAACI position paper

Carina Venter  1   2 , Rosan W Meyer  3 , Matthew Greenhawt  1   2 , Isabella Pali-Schöll  4 , Bright Nwaru  5 , Caroline Roduit  6   7 , Eva Untersmayr  8 , Karine Adel-Patient  9 , Ioana Agache  10 , Carlo Agostoni  11   12 , Cezmi A Akdis  7   13 , Mary Feeney  14   15 , Karin Hoffmann-Sommergruber  8 , Nonhlanhla Lunjani  16   17 , Kate Grimshaw  18 , Imke Reese  19 , Peter K Smith  20 , Milena Sokolowska  13 , Emilia Vassilopoulou  21 , Berber Vlieg-Boerstra  22   23 , Shriya Amara  24 , Jens Walter  16   25   26 , Liam O'Mahony  16   25   26
Affiliations
Free article
Review

Role of dietary fiber in promoting immune health-An EAACI position paper

Carina Venter et al. Allergy. 2022 Nov.
Free article

Abstract

Microbial metabolism of specific dietary components, such as fiber, contributes to the sophisticated inter-kingdom dialogue in the gut that maintains a stable environment with important beneficial physiological, metabolic, and immunological effects on the host. Historical changes in fiber intake may be contributing to the increase of allergic and hypersensitivity disorders as fiber-derived metabolites are evolutionarily hardwired into the molecular circuitry governing immune cell decision-making processes. In this review, we highlight the importance of fiber as a dietary ingredient, its effects on the microbiome, its effects on immune regulation, the importance of appropriate timing of intervention to target any potential window of opportunity, and potential mechanisms for dietary fibers in the prevention and management of allergic diseases. In addition, we review the human studies examining fiber or prebiotic interventions on asthma and respiratory outcomes, allergic rhinitis, atopic dermatitis, and overall risk of atopic disorders. While exposures, interventions, and outcomes were too heterogeneous for meta-analysis, there is significant potential for using fiber in targeted manipulations of the gut microbiome and its metabolic functions in promoting immune health.

Keywords: allergy; diet; fiber; nutrition; prebiotics.

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References

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