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Meta-Analysis
. 2022 Jul 8;101(27):e29747.
doi: 10.1097/MD.0000000000029747.

Accelerated-strategy renal replacement therapy for critically ill patients: A systematic review and meta-analysis

Shao-Huan Lan  1 , Chih-Cheng Lai  2 , Shen-Peng Chang  3 , Li-Chin Lu  4 , Shun-Hsing Hung  5 , Wei-Ting Lin  6
Affiliations
Meta-Analysis

Accelerated-strategy renal replacement therapy for critically ill patients: A systematic review and meta-analysis

Shao-Huan Lan et al. Medicine (Baltimore). .

Abstract

Background: The aim of this study was to investigate the clinical effect and safety of accelerated-strategy initiation of renal replacement therapy (RRT) in critically ill patients.

Methods: PubMed, Embase, OVID, EBSCO, and the Cochrane Library databases were searched for relevant articles from inception to December 30, 2020. Only RCTs that compared the clinical efficacy and safety between accelerated-strategy RRT and standard-strategy RRT among critically ill adult patients with acute kidney injury (AKI) were included. The primary outcome was 28-day mortality.

Results: A total of 5279 patients in 12 RCTs were included in this meta-analysis. The 28-day mortality rates of patients treated with accelerated and standard RRT were 37.3% (969/2596) and 37.9% (976/2573), respectively. No significant difference was observed between the groups (OR, 0.92; 95% CI, 0.70-1.12; I2 = 60%). The recovery rates of renal function were 54.5% and 52.5% in the accelerated- and standard-RRT groups, respectively, with no significant difference (OR, 1.03; 95% CI, 0.89-1.19; I2 = 56%). The rate of RRT dependency was similar in the accelerated- and standard-RRT strategies (6.7% vs 5.0%; OR, 1.11; 95% CI, 0.71-1.72; I2 = 20%). The accelerated-RRT group displayed higher risks of hypotension, catheter-related infection, and hypophosphatemia than the standard-RRT group (hypotension: OR, 1.26; 95% CI, 1.10-1.45; I2 = 36%; catheter-related infection: OR, 1.90; 95% CI, 1.17-3.09; I2 = 0%; hypophosphatemia: OR, 2.11; 95% CI, 1.43-3.15; I2 = 67%).

Conclusions: Accelerated RRT does not reduce the risk of death and does not improve the recovery of kidney function among critically ill patients with AKI. In contrast, an increased risk of adverse events was observed in patients receiving accelerated RRT. However, these findings were based on low quality of evidence. Further large-scale RCTs is warranted.

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Conflict of interest statement

The authors of this work have no funding or conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flowchart of the study selection for meta-analysis.
Figure 2.
Figure 2.
Summary of risk of bias.
Figure 3.
Figure 3.
Forest plot for 28-day mortality.
Figure 4.
Figure 4.
Forest plot of the recovery of renal function.
Figure 5.
Figure 5.
Forest plot of renal replacement dependency.
See this image and copyright information in PMC

References

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