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Review
. 2022 Sep;24(9):1149-1157.
doi: 10.1007/s11886-022-01741-1. Epub 2022 Jul 8.

HIV and Global Cardiovascular Health

Anjali Wagle  1 , Erin Goerlich  1 , Wendy S Post  1   2 , Bethel Woldu  1   3   4 , Katherine C Wu  1   2 , Allison G Hays  5   6
Affiliations
Review

HIV and Global Cardiovascular Health

Anjali Wagle et al. Curr Cardiol Rep. 2022 Sep.

Abstract

Purpose of review: Because of effective combination antiretroviral therapy, people living with HIV (PLWH) are living longer but developing chronic age-related conditions including cardiovascular disease (CVD), the leading cause of death globally. This review aims to discuss the epidemiology, mechanisms, and clinical considerations of CVD in PLWH from a global perspective.

Recent findings: PLWH are at greater risk for CVD at chronologically younger ages than those without HIV. Potential underlying mechanisms for CVD in PLWH include systemic inflammation, comorbidities, immune-mediated, or treatment-related mechanisms. There is also risk factor variation based on geographical location, including non-traditional CVD risk factors. CVD is prevalent in PLWH and increasing on a global scale. Further understanding the unique epidemiology, risk factors, and treatment of CVD in this population will improve the care of PLWH.

Keywords: ASCVD; Antiretrovial therapy; Cardiovascular disease; HIV; PLWH.

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