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Editorial
. 2022 Aug 3;10(8):918.
doi: 10.1158/2326-6066.CIR-22-0473.

Direct T-cell Presentation by cDC1: The Key Feature for Cancer Vaccine Success?

Margaux Hubert  1 , Christophe Caux  1   2 , Jenny Valladeau-Guilemond  1
Affiliations
Editorial

Direct T-cell Presentation by cDC1: The Key Feature for Cancer Vaccine Success?

Margaux Hubert et al. Cancer Immunol Res. .

Abstract

In this issue of Cancer Immunology Research, Ferris and colleagues demonstrate that type 1 conventional DC (cDC1) vaccines drive tumor rejection through direct antigen presentation, without the need of endogenous cDC1. This suggests that cDC1-based vaccines could represent an optimal strategy to induce antitumor immunity in patients. See related article by Ferris et al., p. 920 (7) .

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