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Review
. 2022 Aug:55:101249.
doi: 10.1016/j.coviro.2022.101249. Epub 2022 Jul 5.

Immunotherapy for KSHV-associated diseases

Kathryn Lurain  1 , Robert Yarchoan  2 , Ramya Ramaswami  2
Affiliations
Review

Immunotherapy for KSHV-associated diseases

Kathryn Lurain et al. Curr Opin Virol. 2022 Aug.

Abstract

Kaposi sarcoma herpesvirus (KSHV)-associated diseases (Kaposi sarcoma, multicentric Castleman disease, primary effusion lymphoma, and KSHV inflammatory cytokine syndrome) are associated with immune suppression and dysregulation and loss of KSHV-specific immunity. These diseases are most frequent in people living with HIV as well as those with primary or iatrogenic immune deficiencies. KSHV itself can modulate the immune system via viral homologs of host cytokines or downregulation of immune-surface markers altering host immune surveillance. These factors make KSHV-associated diseases prime targets for immunotherapy approaches. Several agents have been studied or are under investigation in KSHV-associated diseases, including monoclonal antibodies, immunomodulatory agents, and therapeutic cytokines. Here, we review the role of immunotherapies in KSHV-associated diseases.

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Figures

Figure 1:
Figure 1:
Overview of mechanisms of action of immunotherapies in KSHV-associated diseases. *Denotes the therapies that are within guidelines and recommendations for treatment
See this image and copyright information in PMC

References

    1. Unemori P, Leslie KS, Hunt PW, Sinclair E, Epling L, Mitsuyasu R, et al. Immunosenescence is associated with presence of Kaposi’s sarcoma in antiretroviral treated HIV infection. Aids. 2013;27(11):1735–42. - PMC - PubMed
    1. Bihl F, Mosam A, Henry LN, Chisholm JV 3rd, Dollard S, Gumbi P, et al. Kaposi’s sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi’s sarcoma. Aids. 2007;21(10):1245–52. - PubMed
    1. Oksenhendler E, Clauvel JP, Jouveshomme S, Davi F, Mansour G. Complete remission of a primary effusion lymphoma with antiretroviral therapy. Am J Hematol. 1998;57(3):266. - PubMed
    1. Guihot A, Dupin N, Marcelin AG, Gorin I, Bedin AS, Bossi P, et al. Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma. The Journal of infectious diseases. 2006;194(8):1078–88. - PubMed
    1. Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, et al. AIDS-Kaposi’s sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. Science. 1989;243(4888):223–6. - PubMed

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