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Comment
. 2022 Jul 7;82(13):2357-2359.
doi: 10.1016/j.molcel.2022.06.014.

The Cupid shuffle: Do enhancers prefer specific promoters?

Hsiao-Lin V Wang  1 , Victor G Corces  2
Affiliations
Comment

The Cupid shuffle: Do enhancers prefer specific promoters?

Hsiao-Lin V Wang et al. Mol Cell. .

Abstract

Two recent reports (Martinez-Ara et al., 2022; Bergman et al., 2022) explore the compatibility between enhancers and promoters and find that enhancers preferentially activate promoters with low intrinsic activity rather than favoring housekeeping or cell-type-specific promoters.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Strategies for investigating CRE-promoter compatibility
(A) Experimental designs by Martinez-Ara et al. (left) and by Bergman et al. (right). (B) Summary of enhancer-promoter compatibility.
See this image and copyright information in PMC

Comment on

References

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