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Comment
. 2022 Jul 7;82(13):2360-2362.
doi: 10.1016/j.molcel.2022.06.018.

A shattering experience

James E Haber  1
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Free article
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A shattering experience

James E Haber. Mol Cell. .
Free article

Abstract

Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromosome-are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybrids.

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Conflict of interest statement

Declaration of interests J.E.H. is on the editorial advisory board of Molecular Cell.

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