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Comment
. 2022 Jul 7;29(7):1007-1008.
doi: 10.1016/j.stem.2022.06.008.

Human Down syndrome microglia are up for a synaptic feast

Ferdi Ridvan Kiral  1 , In-Hyun Park  2
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Human Down syndrome microglia are up for a synaptic feast

Ferdi Ridvan Kiral et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes, rendering it a potential therapeutic target for Down syndrome.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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