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Comment
. 2022 Jul 7;30(7):919-921.
doi: 10.1016/j.str.2022.05.022.

It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors

Raika Pancaroglu  1 , Filip Van Petegem  2
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It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors

Raika Pancaroglu et al. Structure. .
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Abstract

In this issue of Structure, Melville and colleagues used cryo-EM to study the binding of ryanodine receptors to Rycals, compounds with the potential to treat skeletal and cardiac muscle disorders. Unexpectedly, they found that Rycal packs against an ATP in a peripheral pocket, which stabilizes the closed channel state.

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Declaration of interests The authors declare no competing interests.

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