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Editorial
. 2022 Jul 7;30(7):922-924.
doi: 10.1016/j.str.2022.06.003.

Structures of EBI2 shed light on the treatment of autoimmune diseases

Jinkang Shen  1 , Haitao Zhang  2
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Free article
Editorial

Structures of EBI2 shed light on the treatment of autoimmune diseases

Jinkang Shen et al. Structure. .
Free article

Abstract

Oxysterol receptor EBI2 regulates immune responses that mediate the migration of B and T cells and stimulate antibody production. In this issue of Structure, Chen and colleagues present two cryo-EM structures of EBI2 in the inactive and active states that reveal the molecular mechanisms of EBI2 ligand binding and signaling.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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