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. 2022 Jul 8;12(1):11675.
doi: 10.1038/s41598-022-15804-4.

Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants

Elena Bonafiglia #  1 , Elena Gusson #  2 , Rosa Longo  2 , Benjamim Ficial  3 , Maria Giulia Tisato  1 , Sara Rossignoli  1 , Giulia Caltran  4 , Emilio Pedrotti  2 , Renzo Beghini  1 , Giorgio Marchini  2
Affiliations

Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants

Elena Bonafiglia et al. Sci Rep. .

Abstract

This study investigates the impact of antenatal and postnatal infection or inflammation on the onset and progression of Retinopathy of Prematurity (ROP). We retrospectively collected clinical and demographic data of preterm infants with birth weight ≤ 1500 g or gestational age < 30 weeks admitted to the neonatal intensive care unit of Verona from 2015 to 2019. Uni- and multivariable analysis was performed to evaluate the potential effect of selected variables on the occurrence of any stage ROP and its progression to severe ROP, defined as ROP requiring treatment. Two hundred and eighty neonates were enrolled and 60 of them developed ROP (21.4%). Oxygen need for 28 days and late-onset sepsis (LOS) increased the risk of any grade ROP after adjusting for birth weight and gestational age (OR 6.35, 95% CI 2.14-18.85 and OR 2.49, 95% CI 1.04-5.94, respectively). Days of mechanical ventilation and of non-invasive ventilation increased the risk of progression to severe ROP after adjusting for birth weight and gestational age (OR 1.08, CI 1.02-1.14 and OR 1.06, CI 1.01-1.11, respectively). Exposure to infection with production of inflammatory mediators may contribute to increase the risk of ROP occurrence in very preterm neonates.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Study flow diagram. ROP, Retinopathy of prematurity.
See this image and copyright information in PMC

References

    1. Arima M, Fujii Y, Sonoda KH. Translational research in retinopathy of prematurity: from bedside to bench and back again. J. Clin. Med. 2021;10(2):331. doi: 10.3390/jcm10020331. - DOI - PMC - PubMed
    1. Hellström A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet. 2013;382(9902):1445–1457. doi: 10.1016/S0140-6736(13)60178-6. - DOI - PMC - PubMed
    1. Piermarocchi S, et al. Predictive algorithms for early detection of retinopathy of prematurity. Acta Ophthalmol. 2017;95(2):158–164. doi: 10.1111/aos.13117. - DOI - PubMed
    1. Wilson CM, Ells AL, Fielder AR. The challenge of screening for retinopathy of prematurity. Clin Perinatol. 2013;40(2):241–259. doi: 10.1016/j.clp.2013.02.003. - DOI - PubMed
    1. Rivera JC, et al. Retinopathy of prematurity: Inflammation, choroidal degeneration, and novel promising therapeutic strategies. J. Neuroinflammation. 2017;14(1):165. doi: 10.1186/s12974-017-0943-1. - DOI - PMC - PubMed