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. 2022 Jul 9;22(1):1315.
doi: 10.1186/s12889-022-13694-9.

Disability adjusted life years associated with COVID-19 in Denmark in the first year of the pandemic

Sara M Pires  1 , Hernan G Redondo  2 , Laura Espenhain  3 , Lea S Jakobsen  2 , Rebecca Legarth  3 , Marianna Meaidi  4 , Anders Koch  3   5 , Siri Tribler  3 , Tomas Martin-Bertelsen  4 , Steen Ethelberg  3   5
Affiliations

Disability adjusted life years associated with COVID-19 in Denmark in the first year of the pandemic

Sara M Pires et al. BMC Public Health. .

Abstract

Background: Burden of disease studies measure the public health impact of a disease in a society. The aim of this study was to quantify the direct burden of COVID-19 in the first 12 months of the epidemic in Denmark.

Methods: We collected national surveillance data on positive individuals for SARS-CoV-2 with RT-PCR, hospitalization data, and COVID-19 mortality reported in the period between 26th of February, 2020 to 25th of February, 2021. We calculated disability adjusted life years (DALYs) based on the European Burden of Disease Network consensus COVID-19 model, which considers mild, severe, critical health states, and premature death. We conducted sensitivity analyses for two different death-registration scenarios, within 30 and 60 days after first positive test, respectively.

Results: We estimated that of the 211,823 individuals who tested positive to SARS-CoV-2 by RT-PCR in the one-year period, 124,163 (59%; 95% uncertainty interval (UI) 112,782-133,857) had at least mild symptoms of disease. The total estimated disease burden was 30,180 DALYs (95% UI 30,126; 30,242), corresponding to 520 DALYs/100,000. The disease burden was higher in the age groups above 70 years of age, particularly in men. Years of life lost (YLL) contributed with more than 99% of total DALYs. The results of the scenario analysis showed that defining COVID-19-related fatalities as deaths registered up to 30 days after the first positive test led to a lower YLL estimate than when using a 60-days window.

Conclusion: COVID-19 led to a substantial public health impact in Denmark in the first full year of the epidemic. Our estimates suggest that it was the the sixth most frequent cause of YLL in Denmark in 2020. This impact will be higher when including the post-acute consequences of COVID-19 and indirect health outcomes.

Keywords: Burden of disease; COVID-19; Coronavirus; DALY; Denmark; European burden of disease network; Population health; YLD; YLL.

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Conflict of interest statement

None to declare.

Figures

Fig. 1
Fig. 1
Disease model for COVID-19 (adapted from [11]). The dashed boxes describe post-acute health outcomes of COVID-19, which were not included in the study
Fig. 2
Fig. 2
A Disability adjusted life years (DALY) per 100.000 due to COVID-19 in Denmark by age and sex (February 2020-February2021). B Relative contribution of YLD and YLL in females and males to the total DALY by age group
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