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. 2022 Jun 21;19(13):7576.
doi: 10.3390/ijerph19137576.

Erectile Dysfunction in Relation to Metabolic Disorders and the Concentration of Sex Hormones in Aging Men

Rył Aleksandra  1 , Szylińska Aleksandra  1 , Rotter Iwona  1
Affiliations

Erectile Dysfunction in Relation to Metabolic Disorders and the Concentration of Sex Hormones in Aging Men

Rył Aleksandra et al. Int J Environ Res Public Health. .

Abstract

Background: The aim of this study was to analyze the relationship between the prevalence of erectile dysfunction in men as diagnosed by the International Index of Erectile Function (IIEF) questionnaire and the respective levels of sex hormones and biochemical parameters, as well as indices of visceral fat accumulation and activity.

Material and methods: The study comprised 148 male (60-75 years) patients from primary care outpatient clinics in the city of Szczecin (Poland). The men were asked to complete a shortened survey questionnaire with sociodemographic data, as well as a shortened version of the IIEF (five items). Venous blood samples were collected. Total testosterone (TT), estradiol (E2), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), total cholesterol (ChT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), fasting plasma glucose (FPG) and albumin were determined. Lipid accumulation product (LAP) and visceral adiposity index (VAI) were calculated.

Results: A correlation was found in the analysis of LAP index values (OR = 1.017; p = 0.050). The analysis of hormone concentrations showed a correlation between the diagnosed trait and the value of TT (OR = 1.216; p = 0.046) and SHBG (OR = 1.020; p = 0.007).

Conclusions: VAI and LAP have been shown to be good indicators for assessing erectile dysfunction in men over 60 years of age.

Keywords: aging men; body fat; erectile dysfunctions; metabolic disorders; testosterone.

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Conflict of interest statement

The authors declare no conflict of interest. The sponsors had no role in the design, execution, interpretation, or writing of the study.

Figures

Figure 1
Figure 1
Receiver operating characteristics of the concentrations of TT (blue line) and SGBH (red line) for the International Index of Erectile Function.
Figure 2
Figure 2
Receiver operating characteristics of the concentrations of VAI (blue line) and LAP (red line) for the International Index of Erectile Function.
See this image and copyright information in PMC

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