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Review
. 2022 Jun 27;23(13):7139.
doi: 10.3390/ijms23137139.

Effects of Ferroptosis on Male Reproduction

Yang Liu  1 , Xuanhong Cao  1 , Chen He  1 , Xinrui Guo  1 , Hui Cai  1 , Aili Aierken  1 , Jinlian Hua  1 , Sha Peng  1
Affiliations
Review

Effects of Ferroptosis on Male Reproduction

Yang Liu et al. Int J Mol Sci. .

Abstract

Ferroptosis is a relatively novel form of regulated cell death that was discovered in 2012. With the increasing research related to the mechanisms of ferroptosis, previous studies have demonstrated that the inactive of the intracellular antioxidant system and iron overload can result in the accumulation of reactive oxygen species (ROS), which can ultimately cause lipid peroxidation in the various cell types of the body. ROS accumulation can cause sperm damage by attacking the plasma membrane and damaging DNA. Acute ferroptosis causes oxidative damage to sperm DNA and testicular oxidative stress, thereby causing male reproductive dysfunction. This review aims to discuss the metabolic network of ferroptosis, summarize and analyze the relationship between male reproductive diseases caused by iron overload as well as lipid peroxidation, and provide a novel direction for the research and prevention of various male reproductive diseases.

Keywords: ferroptosis; iron metabolism; male reproductive disorders; oxidative stress.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular mechanisms and signaling pathways of ferroptosis.
Figure 2
Figure 2
A schematic model describing iron absorption and storage in the body.
Figure 3
Figure 3
A schematic model describing the potential role of ferroptosis in triggering male spermatogenesis disorders.
See this image and copyright information in PMC

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