Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 4;11(13):3874.
doi: 10.3390/jcm11133874.

Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population

Zoran Kovacevic  1 , Tatjana Lazarevic  1   2 , Nela Maksimovic  3 , Milka Grk  3 , Vladislav Volarevic  4   5 , Marina Gazdic Jankovic  5 , Svetlana Djukic  2   6 , Katarina Janicijevic  7 , Marina Miletic Kovacevic  8 , Biljana Ljujic  5
Affiliations

Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population

Zoran Kovacevic et al. J Clin Med. .

Abstract

Galectin 3 plays a significant role in the development of chronic renal failure, particularly end-stage renal disease (ESRD). The aim of our study was to investigate the association between Gal-3 and biochemical parameters and primary disease in ESRD patients, by exploring the polymorphisms LGALS3 rs4644, rs4652, and rs11125. A total of 108 ESRD patients and 38 healthy controls were enrolled in the study. Genotyping of LGALS3 gene rs4644, rs4652, and rs11125 polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). By multivariate logistic regression analysis, we found that LGALS3 rs4644 CC and rs4652 AA genotypes were significantly associated with a higher risk for lower hemoglobin, higher level of parathyroid hormone, and also occurrence of diabetes mellitus and arterial hypertension. The CAA haplotype was significantly more common in patients with diabetes, low hemoglobin level, and normal PTH level. It has been observed as well that the ACT haplotype was more common in patients with low glomerular filtration, low PTH, and normal hemoglobin level. We found that the LGALS3 rs4644 and rs4652 gene polymorphism may be involved in the pathogenesis and appearance of complications in ESRD patients and thus could be considered a new genetic risk factor in this population.

Keywords: arterial hypertension; diabetes mellitus; end-stage renal disease; galectin 3; polymorphisms.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of LD with values of D’ (A) and r2 (B) among the analyzed polymorphisms of LGALS3 genes (rs4644, rs4652, and rs11125) in patients with renal disease. (A) Intense red color indicates a value of D’ = 100 for LOD values > 2. The decrease in the intensity of red is proportional to the decrease in the value of D’. (B) The black color is present at the value r2 = 100. The intensity of the gray color is proportional to the values of r2, where the white color corresponds to the value of r2 = 0.
Figure 2
Figure 2
Frequency of haplotypes present in patients.
See this image and copyright information in PMC

References

    1. Lo L.J., Go A.S., Chertow G.M., McCulloch C.E., Fan D., Ordonez J.D., Hsu C.Y. Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int. 2009;76:893–899. doi: 10.1038/ki.2009.289. - DOI - PMC - PubMed
    1. O’Seaghdha C.M., Fox C.S. Genome-wide association studies of chronic kidney disease: What have we learned? Nat. Rev. Nephrol. 2011;8:89–99. doi: 10.1038/nrneph.2011.189. - DOI - PMC - PubMed
    1. Leffler H., Carlsson S., Hedlund M., Qian Y., Poirier F. Introduction to galectins. Glycoconj. J. 2004;19:433–440. doi: 10.1023/B:GLYC.0000014072.34840.04. - DOI - PubMed
    1. Yang R.Y., Rabinovich G.A., Liu F.T. Galectins: Structure, function and therapeutic potential. Expert. Rev. Mol. Med. 2008;10:e17. doi: 10.1017/S1462399408000719. - DOI - PubMed
    1. Dumic J., Dabelic S., Flogel M. Galectin-3: An open-ended story. Biochim. Biophys. Acta. 2006;1760:616–635. doi: 10.1016/j.bbagen.2005.12.020. - DOI - PubMed

LinkOut - more resources