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Randomized Controlled Trial
. 2022 Jun 28;14(13):2674.
doi: 10.3390/nu14132674.

Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies

Nele Gheldof  1 , Celia Francey  1 , Andreas Rytz  2 , Léonie Egli  1 , Frederik Delodder  2 , Lionel Bovetto  3 , Nathalie Piccardi  2 , Christian Darimont  1
Affiliations
Randomized Controlled Trial

Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies

Nele Gheldof et al. Nutrients. .

Abstract

Postprandial hyperglycemia is an important risk factor in the development and progression of type-2 diabetes and cardiometabolic diseases. Therefore, maintaining a low postprandial glucose response is key in preventing these diseases. Carbohydrate-rich meals are the main drivers of excessive glycemic excursions during the day. The consumption of whey protein premeals or mulberry leaf extract was reported to reduce postprandial glycemia through different mechanisms of action. The efficacy of these interventions was shown to be affected by the timing of the consumption or product characteristics. Two randomised crossover studies were performed, aiming to identify the optimal conditions to improve the efficacy of these nutritional supplements in reducing a glycemic response. The acute postprandial glycemic response was monitored with a continuous glucose monitoring device. The first study revealed that a preparation featuring 10 g of whey protein microgel reduced the postprandial glucose response by up to 30% (p = 0.001) and was more efficient than the whey protein isolates, independently of whether the preparation was ingested 30 or 10 min before a complete 320 kcal breakfast. The second study revealed that a preparation featuring 250 mg mulberry leaf extract was more efficient if it was taken together with a complete 510 kcal meal (−34%, p < 0.001) rather than ingested 5 min before (−26%, p = 0.002). These findings demonstrate that the efficacy of whey proteins premeal and mulberry leaf extracts can be optimised to provide potential nutritional solutions to lower the risk of type-2 diabetes or its complications.

Keywords: blood glucose; diabetes mellitus; glycemic response; mulberry (Morus alba) leaf extract; whey protein.

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Conflict of interest statement

All the authors were employees of Nestlé Research (Lausanne, Switzerland) at the time of the study’s conduct.

Figures

Figure 1
Figure 1
Flowchart of the two studies, including enrollment, allocation, and analysis.
Figure 2
Figure 2
Average 2h-PPGR of the protein premeal study featuring n = 14 completers, with premeal taken either 30 min before (a) or 10 min before (b) the complete breakfast with an estimated GL of 48 g, and average 2h-PPGR of the MLE study featuring n = 30 subjects (c). The figure shows cross-sectional values with mean ± SE.
See this image and copyright information in PMC

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