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Review
. 2022 Jul 1;14(13):2747.
doi: 10.3390/nu14132747.

Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury

Hema Gandecha  1   2 , Avineet Kaur  1   2 , Ranveer Sanghera  1   2 , Joanna Preece  1 , Thillagavathie Pillay  1   3   4
Affiliations
Review

Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury

Hema Gandecha et al. Nutrients. .

Abstract

Perinatal hypoxia ischaemia (PHI), acute and chronic, may be associated with considerable adverse outcomes in the foetus and neonate. The molecular and cellular mechanisms of injury and repair associated with PHI in the perinate are not completely understood. Increasing evidence is mounting for the role of nutrients and bioactive food components in immune development, function and repair in PHI. In this review, we explore current concepts around the neonatal immune response to PHI with a specific emphasis on the impact of nutrition in the mother, foetus and neonate.

Keywords: IUGR (intrauterine growth restriction); hypoxia; immunity; ischaemia; newborn; nutrition; nutrition immune axis; nutritional immunology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The perinatal immune repertoire: examples of differences in defence and immunity in the perinatal period compared to older children and adults. Image created using Biorender.com (accessed on 29 May 2022).
Figure 2
Figure 2
The nutrition–microbiome–immune axis in perinatal hypoxia-ischaemia (PHI): the interrelationship between perinatal nutrition, the maternal, placental and neonatal microbiome, and immunity (altered inflammatory response: injury, protection and repair) in the perinatal (foetal and neonatal) period is illustrated. Image created using Biorender.com (accessed on 29 May 2022).
See this image and copyright information in PMC

References

    1. Novak C.M., Ozen M., Burd I. Perinatal Brain Injury. Clin. Perinatol. 2018;45:357–375. doi: 10.1016/j.clp.2018.01.015. - DOI - PubMed
    1. Kollmann T.R., Kampmann B., Mazmanian S.K., Marchant A., Levy O. Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. Immunity. 2017;46:350–363. doi: 10.1016/j.immuni.2017.03.009. - DOI - PubMed
    1. Zhang X., Zhivaki D., Lo-Man R. Unique Aspects of the Perinatal Immune System. Nat. Rev. Immunol. 2017;17:495–507. doi: 10.1038/nri.2017.54. - DOI - PubMed
    1. Rizzuto G., Erlebacher A. Trophoblast Antigens, Fetal Blood Cell Antigens, and the Paradox of Fetomaternal Tolerance. J. Exp. Med. 2022;219:e20211515. doi: 10.1084/jem.20211515. - DOI - PMC - PubMed
    1. Petroff M.G. Review: Fetal Antigens—Identity, Origins, and Influences on the Maternal Immune System. Placenta. 2011;32:S176–S181. doi: 10.1016/j.placenta.2010.12.014. - DOI - PMC - PubMed

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