ESCRTed resistance to T cell attack

Simona Maria Migliano¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
² Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Faculty of Medicine, N-7491 Trondheim, Norway. Electronic address: stenmark@ulrik.uio.no.

PMID: 35810056
DOI: 10.1016/j.it.2022.06.007

Comment

ESCRTed resistance to T cell attack

Simona Maria Migliano et al. Trends Immunol. 2022 Aug.

. 2022 Aug;43(8):598-600.

doi: 10.1016/j.it.2022.06.007. Epub 2022 Jul 6.

Authors

Simona Maria Migliano¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
² Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Faculty of Medicine, N-7491 Trondheim, Norway. Electronic address: stenmark@ulrik.uio.no.

PMID: 35810056
DOI: 10.1016/j.it.2022.06.007

Abstract

Cytotoxic T cells kill target cells such as cancer cells by making pores in their plasma membrane through which toxic enzymes are secreted. Ritter and colleagues now show that cancer cells can actively remove such pores via the action of endosomal sorting complex required for transport (ESCRT) proteins, thereby counteracting CD8⁺ T cell-mediated killing.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack.
Ritter AT, Shtengel G, Xu CS, Weigel A, Hoffman DP, Freeman M, Iyer N, Alivodej N, Ackerman D, Voskoboinik I, Trapani J, Hess HF, Mellman I. Ritter AT, et al. Science. 2022 Apr 22;376(6591):377-382. doi: 10.1126/science.abl3855. Epub 2022 Apr 21. Science. 2022. PMID: 35446649

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

ESCRTed resistance to T cell attack

Affiliations

ESCRTed resistance to T cell attack

Authors

Affiliations

Abstract

Conflict of interest statement

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Research Materials