Combined Deep Learning-based Super-Resolution and Partial Fourier Reconstruction for Gradient Echo Sequences in Abdominal MRI at 3 Tesla: Shortening Breath-Hold Time and Improving Image Sharpness and Lesion Conspicuity

Abstract

Rationale and objectives: To investigate the impact of a prototypical deep learning-based super-resolution reconstruction algorithm tailored to partial Fourier acquisitions on acquisition time and image quality for abdominal T1-weighted volume-interpolated breath-hold examination (VIBE_SR) at 3 Tesla. The standard T1-weighted images were used as the reference standard (VIBE_SD).

Materials and methods: Patients with diverse abdominal pathologies, who underwent a clinically indicated contrast-enhanced abdominal VIBE magnetic resonance imaging at 3T between March and June 2021 were retrospectively included. Following the acquisition of the standard VIBE_SD sequences, additional images for the non-contrast, dynamic contrast-enhanced and post-contrast T1-weighted VIBE acquisition were retrospectively reconstructed using the same raw data and employing a prototypical deep learning-based super-resolution reconstruction algorithm. The algorithm was designed to enhance edge sharpness by avoiding conventional k-space filtering and to perform a partial Fourier reconstruction in the slice phase-encoding direction for a predefined asymmetric sampling ratio. In the retrospective reconstruction, the asymmetric sampling was realized by omitting acquired samples at the end of the acquisition and therefore corresponding to a shorter acquisition. Four radiologists independently analyzed the image datasets (VIBE_SR and VIBE_SD) in a blinded manner. Outcome measures were: sharpness of abdominal organs, sharpness of vessels, image contrast, noise, hepatic lesion conspicuity and size, overall image quality and diagnostic confidence. These parameters were statistically compared and interrater reliability was computed using Fleiss' Kappa and intraclass correlation coefficient (ICC). Finally, the rate of detection of hepatic lesions was documented and was statistically compared using the paired Wilcoxon test.

Results: A total of 32 patients aged 59 ± 16 years (23 men (72%), 9 women (28%)) were included. For VIBE_SR, breath-hold time was significantly reduced by approximately 13.6% (VIBE_SR 11.9 ± 1.2 seconds vs. VIBE_SD: 13.9 ± 1.4 seconds, p < 0.001). All readers rated sharpness of abdominal organs, sharpness of vessels to be superior in images with VIBE_SR (p values ranged between p = 0.005 and p < 0.001). Despite reduction of acquisition time, image contrast, noise, overall image quality and diagnostic confidence were not compromised, as there was no evidence of a difference between VIBE_SR and VIBE_SD (p > 0.05). The inter-reader agreement was substantial with a Fleiss' Kappa of >0.7 in all contrast phases. A total of 13 hepatic lesions were analyzed. The four readers observed a superior lesion conspicuity in VIBE_SR than in VIBE_SD (p values ranged between p = 0.046 and p < 0.001). In terms of lesion size, there was no significant difference between VIBE_SD and VIBE_SR for all readers. Finally, there was an excellent inter-reader agreement regarding lesion size (ICC > 0.9). For all readers, no statistically significant difference was observed regarding detection of hepatic lesions between VIBE_SD and VIBE_SR.

Conclusion: The deep learning-based super-resolution reconstruction with partial Fourier in the slice phase-encoding direction enabled a reduction of breath-hold time and improved image sharpness and lesion conspicuity in T1-weighted gradient echo sequences in abdominal magnetic resonance imaging at 3 Tesla. Faster acquisition time without compromising image quality or diagnostic confidence was possible by using this deep learning-based reconstruction technique.

Keywords: VIBE sequence; abdominal MRI; acceleration; deep learning; parallel acquisition techniques.