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Meta-Analysis
. 2022 Dec;159(3):651-661.
doi: 10.1002/ijgo.14336. Epub 2022 Jul 29.

COVID-19 vaccine and pregnancy outcomes: A systematic review and meta-analysis

Luigi Carbone  1 , Maria Giuseppina Trinchillo  1 , Raffaella Di Girolamo  1 , Antonio Raffone  2 , Gabriele Saccone  1 , Giuseppe Gabriele Iorio  1 , Olimpia Gabrielli  1 , Giuseppe Maria Maruotti  1
Affiliations
Meta-Analysis

COVID-19 vaccine and pregnancy outcomes: A systematic review and meta-analysis

Luigi Carbone et al. Int J Gynaecol Obstet. 2022 Dec.

Abstract

Objectives: To explore perinatal outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-vaccinated pregnant women compared with unvaccinated counterparts.

Methods: Search was conducted using Web of Science, Scopus, ClinicalTrial.gov, MEDLINE, Embase, OVID, and Cochrane Library as electronic databases. We included observational studies evaluating pregnant women undergoing SARS-CoV-2 vaccination and compared pregnancy and perinatal outcomes with those in unvaccinated women. Categorical variables were assessed using odds ratio (OR) with 95% confidence interval (CI), whereas for continuous variables, the results were expressed as mean difference with their 95% CI. All analyses were performed by adopting the random effect model of DerSimonian and Laird.

Results: There was no difference in the probability of having a small-for-gestational-age fetus (OR 0.97, 95% CI 0.85-1.09; P = 0.570), but we observed a reduced probability of a non-reassuring fetal monitoring, a reduced gestational age at delivery, and a reduced probability of premature delivery in vaccinated pregnant women versus unvaccinated ones.

Conclusion: The probability of small for gestational age is similar between vaccinated and unvaccinated pregnant women, and the former also had a slightly reduced rate of premature delivery.

Keywords: coronavirus disease 2019; meta-analysis; pregnancy; preterm birth; severe acute respiratory syndrome coronavirus 2; small for gestational age; systematic review; vaccine.

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Conflict of interest statement

The authors reports no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of studies identified in the systematic review.
FIGURE 2
FIGURE 2
Forest plot for the mean difference of gestational age at delivery.
FIGURE 3
FIGURE 3
Forest plot for the odds ratio of preterm delivery.
FIGURE 4
FIGURE 4
Forest plot for the odds ratio of non‐reassuring fetal monitoring.
See this image and copyright information in PMC

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References

    1. Franchi M, Bosco M, Garzon S, et al. Management of obstetrics and gynaecological patients with COVID‐19. Italian J Obstet Gynecol. 2020;32(1):6‐19. doi:10.36129/jog.32.01.01 - DOI
    1. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus disease 2019 (COVID‐19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415‐426. doi:10.1016/j.ajog.2020.02.017 - DOI - PMC - PubMed
    1. Carbone IF, Conforti A, Farina A, Alviggi C. A practical approach for the management of obstetric and infertile women during the phase two of the novel coronavirus disease 2019 (COVID ‐19) pandemic. Eur J Obstet Gynecol Reprod Biol. 2020;251:266‐267. doi:10.1016/j.ejogrb.2020.06.006 - DOI - PMC - PubMed
    1. Carbone L, Raffone A, Travaglino A, et al. Obstetric a&E unit admission and hospitalization for obstetrical management during COVID‐19 pandemic in a third‐level hospital of southern Italy. Arch Gynecol Obstet. 2021;29:1‐9. doi:10.1007/s00404-021-06212-6 - DOI - PMC - PubMed
    1. Picarelli S, Conforti A, Buonfantino C, et al. IVF during coronavirus pandemic: who comes first? The POSEIDON viewpoint. Italian J Gynaecol Obstet. 2020;32(4):223‐228. doi:10.36129/jog.32.04.01 - DOI

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