Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Dec;159(3):651-661.
doi: 10.1002/ijgo.14336. Epub 2022 Jul 29.

COVID-19 vaccine and pregnancy outcomes: A systematic review and meta-analysis

Luigi Carbone  1 , Maria Giuseppina Trinchillo  1 , Raffaella Di Girolamo  1 , Antonio Raffone  2 , Gabriele Saccone  1 , Giuseppe Gabriele Iorio  1 , Olimpia Gabrielli  1 , Giuseppe Maria Maruotti  1
Affiliations
Meta-Analysis

COVID-19 vaccine and pregnancy outcomes: A systematic review and meta-analysis

Luigi Carbone et al. Int J Gynaecol Obstet. 2022 Dec.

Abstract

Objectives: To explore perinatal outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-vaccinated pregnant women compared with unvaccinated counterparts.

Methods: Search was conducted using Web of Science, Scopus, ClinicalTrial.gov, MEDLINE, Embase, OVID, and Cochrane Library as electronic databases. We included observational studies evaluating pregnant women undergoing SARS-CoV-2 vaccination and compared pregnancy and perinatal outcomes with those in unvaccinated women. Categorical variables were assessed using odds ratio (OR) with 95% confidence interval (CI), whereas for continuous variables, the results were expressed as mean difference with their 95% CI. All analyses were performed by adopting the random effect model of DerSimonian and Laird.

Results: There was no difference in the probability of having a small-for-gestational-age fetus (OR 0.97, 95% CI 0.85-1.09; P = 0.570), but we observed a reduced probability of a non-reassuring fetal monitoring, a reduced gestational age at delivery, and a reduced probability of premature delivery in vaccinated pregnant women versus unvaccinated ones.

Conclusion: The probability of small for gestational age is similar between vaccinated and unvaccinated pregnant women, and the former also had a slightly reduced rate of premature delivery.

Keywords: coronavirus disease 2019; meta-analysis; pregnancy; preterm birth; severe acute respiratory syndrome coronavirus 2; small for gestational age; systematic review; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors reports no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of studies identified in the systematic review.
FIGURE 2
FIGURE 2
Forest plot for the mean difference of gestational age at delivery.
FIGURE 3
FIGURE 3
Forest plot for the odds ratio of preterm delivery.
FIGURE 4
FIGURE 4
Forest plot for the odds ratio of non‐reassuring fetal monitoring.
See this image and copyright information in PMC

References

    1. Franchi M, Bosco M, Garzon S, et al. Management of obstetrics and gynaecological patients with COVID‐19. Italian J Obstet Gynecol. 2020;32(1):6‐19. doi:10.36129/jog.32.01.01 - DOI
    1. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus disease 2019 (COVID‐19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415‐426. doi:10.1016/j.ajog.2020.02.017 - DOI - PMC - PubMed
    1. Carbone IF, Conforti A, Farina A, Alviggi C. A practical approach for the management of obstetric and infertile women during the phase two of the novel coronavirus disease 2019 (COVID ‐19) pandemic. Eur J Obstet Gynecol Reprod Biol. 2020;251:266‐267. doi:10.1016/j.ejogrb.2020.06.006 - DOI - PMC - PubMed
    1. Carbone L, Raffone A, Travaglino A, et al. Obstetric a&E unit admission and hospitalization for obstetrical management during COVID‐19 pandemic in a third‐level hospital of southern Italy. Arch Gynecol Obstet. 2021;29:1‐9. doi:10.1007/s00404-021-06212-6 - DOI - PMC - PubMed
    1. Picarelli S, Conforti A, Buonfantino C, et al. IVF during coronavirus pandemic: who comes first? The POSEIDON viewpoint. Italian J Gynaecol Obstet. 2020;32(4):223‐228. doi:10.36129/jog.32.04.01 - DOI

Substances