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. 2022 Sep 15:370:577925.
doi: 10.1016/j.jneuroim.2022.577925. Epub 2022 Jul 2.

IL-6 as a marker for NMOSD disease activity

Adi Haramati  1 , Ariel Rechtman  2 , Omri Zveik  2 , Nitzan Haham  2 , Livnat Brill  2 , Adi Vaknin-Dembinsky  3
Affiliations

IL-6 as a marker for NMOSD disease activity

Adi Haramati et al. J Neuroimmunol. .

Abstract

To date, there are no accepted soluble markers for disease activity and progression of neuromyelitis optica spectrum disorder (NMOSD). We aimed to evaluate longitudinal interleukin (IL)-6 levels in sera of NMOSD patients in correlation with disease activity and brain volume. We analyzed IL-6 serum levels of 26 NMOSD patients during relapse and remission. Significantly increased IL-6 levels were detected in patients with NMOSD during relapse. Furthermore, increased IL-6 levels correlated with relapse severity and brain atrophy. Our findings suggest that IL-6 serum level could serve as a biomarker for disease activity in NMOSD.

Keywords: Biomarker; Brain volume; Interleukin 6; Neuromyelitis Optica; Relapse.

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