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. 2023 Jul 29;61(4):250-259.
doi: 10.2486/indhealth.2021-0233. Epub 2022 Oct 7.

Increased job strain and cardiovascular disease mortality: a prospective cohort study in U.S. workers

Timothy A Matthews  1 , Liwei Chen  2 , Jian Li  1   3
Affiliations

Increased job strain and cardiovascular disease mortality: a prospective cohort study in U.S. workers

Timothy A Matthews et al. Ind Health. .

Abstract

Job strain is considered a potential risk factor of cardiovascular disease (CVD). Our objective was to examine prospective associations of job strain with CVD mortality using data from the national, population-based Mid-life in the United States (MIDUS) cohort study, while considering changes in job strain. Job strain measure was based on Demand-Control model at Wave 1 in 1995-1996 and Wave 2 in 2004-2006, and CVD mortality data through 2018 were retrieved through linkage to the National Death Index (NDI). Cox proportional hazards regression was applied to assess prospective associations between job strain across MIDUS I and MIDUS II and CVD mortality at follow-up in 1,870 workers free from CVD at MIDUS I. After adjustment for relevant covariates, single measurement of job strain at MIDUS I or MIDUS II, and two measurements of job strain between the two waves were not significantly associated with CVD mortality, while the increase in scores between the two waves (increase vs. no increase) demonstrated stronger prospective associations with CVD mortality (HR and 95% CI = 2.37 [0.88, 6.42]). Our findings suggest increased job strain may pose a stronger risk to CVD mortality than single exposure measurement.

Keywords: Cardiovascular disease mortality; Changes; Cohort study; Job strain.

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Conflict of interest statement

The authors of this manuscript declare that they have no conflicting interests.

Figures

Fig. 1.
Fig. 1.
Sample size selection.
Fig. 2.
Fig. 2.
Model of associations between job strain (MIDUS I and MIDUS II) with cardiovascular disease (CVD) mortality (N=1,870).
See this image and copyright information in PMC

References

    1. Giedrimiene D, King R. (2017) Abstract 207: Burden of Cardiovascular Disease (CVD) on economic cost. Comparison of outcomes in US and Europe. Circ Cardiovasc Qual Outcomes 10, A207.
    1. Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee (2020) Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation 141, e139–596. - PubMed
    1. Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O’Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee (2019) Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Circulation 139, e56–528. - PubMed
    1. Heron M. (2019) Deaths: leading causes for 2017. Natl Vital Stat Rep 68, 1–77. - PubMed
    1. Kivimäki M, Nyberg ST, Batty GD, Fransson EI, Heikkilä K, Alfredsson L, Bjorner JB, Borritz M, Burr H, Casini A, Clays E, De Bacquer D, Dragano N, Ferrie JE, Geuskens GA, Goldberg M, Hamer M, Hooftman WE, Houtman IL, Joensuu M, Jokela M, Kittel F, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Kumari M, Madsen IE, Marmot MG, Nielsen ML, Nordin M, Oksanen T, Pentti J, Rugulies R, Salo P, Siegrist J, Singh-Manoux A, Suominen SB, Väänänen A, Vahtera J, Virtanen M, Westerholm PJ, Westerlund H, Zins M, Steptoe A, Theorell T, IPD-Work Consortium (2012) Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet 380, 1491–7. - PMC - PubMed

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