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Multicenter Study
. 2022 Jul;37(4):800-810.
doi: 10.3904/kjim.2021.348. Epub 2022 Jun 28.

Microbiologic pattern and clinical outcome of non-ICU-acquired pneumonia: Korean HAP registry analysis

Jin Ho Jang  1   2 , Hye Ju Yeo  1   2 , Taehwa Kim  1   2 , Woo Hyun Cho  1   2 , Kyung Hoon Min  3 , Sang-Bum Hong  4 , Ae-Rin Baek  5 , Hyun-Kyung Lee  6 , Changhwan Kim  7 , Youjin Chang  8 , Hye Kyeong Park  9 , Jee Youn Oh  3 , Heung Bum Lee  10 , Soohyun Bae  11 , Jae Young Moon  12 , Kwang Ha Yoo  13 , Hyun-Il Gil  14 , Kyeongman Jeon  15 ; Korean HAP/VAP Study Group  1
Affiliations
Multicenter Study

Microbiologic pattern and clinical outcome of non-ICU-acquired pneumonia: Korean HAP registry analysis

Jin Ho Jang et al. Korean J Intern Med. 2022 Jul.

Erratum in

Abstract

Background/aims: Most studies on hospital-acquired pneumonia (HAP) have been conducted in intensive care unit (ICU) settings. This study aimed to investigate the microbiological and clinical characteristics of non-ICU-acquired pneumonia (NIAP) and to identify the factors affecting clinical outcomes in Korea.

Methods: This multicenter retrospective cohort study was conducted in patients admitted to 13 tertiary hospitals between July 1, 2019 and December 31, 2019. Patients diagnosed with NIAP were included in this study. To assess the prognostic factors of NIAP, the study population was classified into treatment success and failure groups.

Results: Of 526 patients with HAP, 379 were diagnosed with NIAP. Overall, the identified causative pathogen rate was 34.6% in the study population. Among the isolated organisms (n = 113), gram-negative bacilli were common pathogens (n = 91), such as Pseudomonas aeruginosa (n = 25), Acinetobacter baumannii (n = 23), and Klebsiella pneumoniae (n = 21). The multidrug resistance rates of A. baumannii, P. aeruginosa, and K. pneumoniae were 91.3%, 76.0%, and 57.1%, respectively. Treatment failure was significantly associated with K. pneumoniae (odds ratio [OR], 3.50; 95% confidence interval [CI], 1.35 to 9.05; p = 0.010), respiratory viruses (OR, 3.81; 95% CI, 1.34 to 10.82; p = 0.012), hematological malignancies (OR, 3.54; 95% CI, 1.57 to 8.00; p = 0.002), and adjunctive corticosteroid treatment (OR, 2.40; 95% CI, 1.27 to 4.52; p = 0.007).

Conclusion: The causative pathogens of NIAP in Korea are predominantly gram-negative bacilli with a high rate of multidrug resistance. These were not different from the common pathogens of ICU-acquired pneumonia.

Keywords: General ward; Healthcare-associated pneumonia; Korea; Microbiology; Prognosis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Flow chart of patient’s enrollment. In total, 379 patients were included in the study. HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; ICU, intensive care unit; NIAP, non-ICU-acquired pneumonia.
None
See this image and copyright information in PMC

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