Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar;290(5):1161-1185.
doi: 10.1111/febs.16573. Epub 2022 Aug 2.

Context-dependent roles of cellular senescence in normal, aged, and disease states

Victoria Moiseeva  1 , Andrés Cisneros  1 , Aina Calls Cobos  1 , Aida Beà Tarrega  1 , Claudia Santos Oñate  1 , Eusebio Perdiguero  1 , Antonio L Serrano  1 , Pura Muñoz-Cánoves  1   2   3
Affiliations
Free article
Review

Context-dependent roles of cellular senescence in normal, aged, and disease states

Victoria Moiseeva et al. FEBS J. 2023 Mar.
Free article

Abstract

Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue damage and in age-related diseases. Through the production of a multicomponent secretory phenotype (SASP), senescent cells can impact the regeneration and function of tissues. However, the effects of senescent cells and their SASP are very heterogeneous and depend on the tissue environment and type as well as the duration of injury, the degree of persistence of senescent cells and the organism's age. While the transient presence of senescent cells is widely believed to be beneficial, recent data suggest that it is detrimental for tissue regeneration after acute damage. Furthermore, although senescent cell persistence is typically associated with the progression of age-related chronic degenerative diseases, it now appears to be also necessary for correct tissue function in the elderly. Here, we discuss what is currently known about the roles of senescent cells and their SASP in tissue regeneration in ageing and age-related diseases, highlighting their (negative and/or positive) contributions. We provide insight for future research, including the possibility of senolytic-based therapies and cellular reprogramming, with aims ranging from enhancing tissue repair to extending a healthy lifespan.

Keywords: SASP; ageing; disease; regeneration; senescence.

PubMed Disclaimer

References

    1. Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol. 2013;75:685-705. https://doi.org/10.1146/annurev-physiol-030212-183653
    1. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704-7. https://doi.org/10.1038/366704a0
    1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621. https://doi.org/10.1016/0014-4827(61)90192-6
    1. Van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509:439-46. https://doi.org/10.1038/nature13193
    1. Roy AL, Sierra F, Howcroft K, Singer DS, Sharpless N, Hodes RJ, et al. A blueprint for characterizing senescence. Cell. 2020;183:1143-6. https://doi.org/10.1016/j.cell.2020.10.032

Publication types

LinkOut - more resources