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Editorial
. 2022 Jun 23:16:894193.
doi: 10.3389/fnins.2022.894193. eCollection 2022.

Editorial: Home Cage-Based Phenotyping in Rodents: Innovation, Standardization, Reproducibility and Translational Improvement

Stefano Gaburro  1 , York Winter  2 , Maarten Loos  3 , Jeansok J Kim  4 , Oliver Stiedl  5
Affiliations
Editorial

Editorial: Home Cage-Based Phenotyping in Rodents: Innovation, Standardization, Reproducibility and Translational Improvement

Stefano Gaburro et al. Front Neurosci. .
No abstract available

Keywords: animal welfare; cognitive function; early disease symptom detection; home cage monitoring; human disease models; locomotor activity.

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Conflict of interest statement

SG works as scientific director at Tecniplast S.p.A. ML works as Chief Executive Officer at Sylics BV. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Eight single-housed K18-hACE2 (C57Bl/6J background) mice were exposed to the SARS-CoV-2 virus (2.8 × 104 TCID50/ml). Changes in body weight (A) and total distance traveled (B) were assessed for six days relative to pre-inoculation values (100%). After viral exposure (inoculation), body weight dropped significantly on day 4, whereas the distance traveled was already significantly reduced by 30% on day 1 and reduced by almost 90% on day 4 indicating substantially higher sensitivity of locomotor activity than body weight change (Gaburro, ; modified from Kaufmann et al., 2022).
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  • Editorial on the Research Topics Home Cage-Based Phenotyping in Rodents: Innovation, Standardization, Reproducibility and Translational Improvement

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