Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Jun 24:27:101632.
doi: 10.1016/j.ajoc.2022.101632. eCollection 2022 Sep.

Morning glory disc anomaly associated with moyamoya disease and pituitary stalk duplication

Mohamed M Khodeiry  1 , Viet Q Chau  1 , Anas Yasin  1 , Robert M Starke  2 , Shahnaz Miri  1 , Joshua Pasol  1
Affiliations
Case Reports

Morning glory disc anomaly associated with moyamoya disease and pituitary stalk duplication

Mohamed M Khodeiry et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: We report a case of a 10-year-old with Moring glory disc anomaly (MGDA) associated with Moyamoya disease and pituitary stalk duplication.

Observations: A 10-year-old Asian child presented with decreased vision in the right eye and bilateral nystagmus. Both dilated fundus exam and magnetic resonance imaging (MRI) of the orbit confirmed MGDA of the right eye. MRI of the brain demonstrated duplication of the pituitary stalk. Magnetic resonance angiography (MRA) of the brain revealed bilateral severe narrowing (greater on the right side) of the distal supraclinoid internal carotid arteries with bilateral reconstitution at the carotid terminus and prominent collaterals, suggestive of Moyamoya disease.

Conclusions: Patients with MGDA should undergo neuroimaging due to the associated central nervous system (CNS) anomalies.

Keywords: Morning glory disc anomaly; Moyamoya disease.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant conflicts of interest to disclose with this manuscript.

Figures

Fig. 1
Fig. 1
Fundus photograph of the right optic nerve head.
Fig. 2
Fig. 2
Outpouching of the posterior right globe noted in axial T2 scan.
Fig. 3
Fig. 3
Coronal T2-weighted images demonstrated duplication of the pituitary stalk.
Fig. 4
Fig. 4
A. MRA of the head which shows severe narrowing with near occlusion of the bilateral distal supraclinoid internal carotid arteries (yellow arrows). There is reconstitution noted at the carotid terminus bilaterally. B. There are additionally prominent collateral vessels arising from the bilateral M1, A1 and posterior communicating arteries. These findings are keeping with Moyamoya disease. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Quah B.L., Hamilton J., Blaser S., Héon E., Tehrani N.N. Morning glory disc anomaly, midline cranial defects and abnormal carotid circulation: an association worth looking for. Pediatr Radiol. 2005;35(5):525–528. - PubMed
    1. Harasymowycz P., Chevrette L., Décarie J.C., et al. Morning glory syndrome: clinical, computerized tomographic, and ultrasonographic findings. J Pediatr Ophthalmol Strabismus. 2005;42(5):290–295. - PubMed
    1. Inoue M. Retinal complications associated with congenital optic disc anomalies determined by swept source optical coherence tomography. Taiwan J Ophthalmol. 2016;6(1):8–14. - PMC - PubMed
    1. Zhang H., Zheng L., Feng L. Epidemiology, diagnosis and treatment of moyamoya disease. Exp Ther Med. 2019;17(3):1977–1984. - PMC - PubMed
    1. Ghaffari-Rafi A., Ghaffari-Rafi S., Leon-Rojas J. Socioeconomic and demographic disparities of moyamoya disease in the United States. Clin Neurol Neurosurg. 2020;192(105719) - PubMed

Publication types

LinkOut - more resources