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. 2022 May 2;49(3):129-142.
doi: 10.1159/000524353. eCollection 2022 Jun.

Platelet-Rich Plasma in Plastic Surgery: A Systematic Review

Sophie K Hasiba-Pappas  1 , Alexandru Cristian Tuca  1 , Hanna Luze  1 , Sebastian P Nischwitz  1 , Robert Zrim  1 , Judith C J Geißler  1 , David Benjamin Lumenta  1 , Lars-P Kamolz  1   2 , Raimund Winter  1
Affiliations

Platelet-Rich Plasma in Plastic Surgery: A Systematic Review

Sophie K Hasiba-Pappas et al. Transfus Med Hemother. .

Abstract

Introduction: Platelet-rich plasma (PRP) is gaining popularity and is applied in a variety of clinical settings. This review aims to present and evaluate available evidence regarding the use of PRP in various applications in plastic surgery.

Methods: PubMed, Web of Science, Medline, and Embase were searched using predefined MeSH terms to identify studies concerning the application of PRP alone or in combination with fat grafting for plastic surgery. The search was limited to articles in English or German. Animal studies, in vitro studies, case reports, and case series were excluded.

Results: Of 50 studies included in this review, eleven studies used PRP for reconstruction or wound treatment, eleven for cosmetic procedures, four for hand surgery, two for burn injuries, five for craniofacial disorders, and 17 as an adjuvant to fat grafting. Individual study characteristics were summarized. Considerable variation in preparation protocols and treatment strategies were observed. Even though several beneficial effects of PRP therapy were described, significance was not always demonstrated, and some studies yielded conflicting results. Efficacy of PRP was not universally proven in every field of application.

Conclusion: This study presents an overview of current PRP treatment options and outcomes in plastic surgery. PRP may be beneficial for some indications explored in this review; however, currently available data are insufficient and systematic evaluation is limited due to high heterogeneity in PRP preparation and treatment regimens. Further randomized controlled trials employing standardized protocols are warranted.

Keywords: Autologous blood products; Healing; Therapy.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Flowchart describing the review process.
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References

    1. Sommeling CE, Heyneman A, Hoeksema H, Verbelen J, Stillaert FB, Monstrey S. The use of platelet-rich plasma in plastic surgery: a systematic review. J Plast Reconstr Aesthet Surg. 2013 Mar;66((3)):301–11. - PubMed
    1. Alves R, Grimalt R. A review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018 Jan;4:18–24. - PMC - PubMed
    1. Xie X, Zhang C, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 2014 Feb;16:204. - PMC - PubMed
    1. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001 Dec;10((4)):225–8. - PubMed
    1. Chamata ES, Bartlett EL, Weir D, Rohrich RJ. Platelet-rich plasma: evolving role in plastic surgery. Plast Reconstr Surg. 2021 Jan;147((1)):219–30. - PubMed

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