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Review
. 2022 Jun 23:13:875425.
doi: 10.3389/fendo.2022.875425. eCollection 2022.

Roles of EP Receptors in the Regulation of Fluid Balance and Blood Pressure

Lu Wang  1   2   3 , Yiqian Wu  1   2   4 , Zhanjun Jia  1   2 , Jing Yu  1   2 , Songming Huang  1   2   4
Affiliations
Review

Roles of EP Receptors in the Regulation of Fluid Balance and Blood Pressure

Lu Wang et al. Front Endocrinol (Lausanne). .

Abstract

Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure, PGE2 is implicated in sustaining volume and hemodynamics homeostasis. PGE2 works through four distinct E-prostanoid (EP) receptors which are G protein-coupled receptors. To date, pharmacological specific antagonists and agonists of all four subtypes of EP receptors and genetic targeting knockout mice for each subtype have helped in uncoupling the diverse functions of PGE2 and discriminating the respective characteristics of each receptor. In this review, we summarized the functions of individual EP receptor subtypes in the renal and blood vessels and the molecular mechanism of PGE2-induced fluid metabolism and blood pressure homeostasis.

Keywords: EP receptors; blood pressure; blood pressure (BP); fluid metabolism; hypertension; kidney; prostaglandin E2.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Generation of PGE2 and Functions in Fluid Balance and Blood Pressure with The EPs.
See this image and copyright information in PMC

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References

    1. Stanhewicz AE, Kenney WL. Determinants of Water and Sodium Intake and Output. Nutr Rev (2015) 73 Suppl 2:73–82. doi: 10.1093/nutrit/nuv033 - DOI - PubMed
    1. Prieto I, Villarejo AB, Segarra AB, Banegas I, Wangensteen R, Martinez-Cañamero M, et al. . Brain, Heart and Kidney Correlate for the Control of Blood Pressure and Water Balance: Role of Angiotensinases. Neuroendocrinology (2014) 100:198–208. doi: 10.1159/000368835 - DOI - PubMed
    1. Saliakoura M, Reynoso-Moreno I, Pozzato C, Rossi Sebastiano M, Galié M, Gertsch J, et al. . The ACSL3-LPIAT1 Signaling Drives Prostaglandin Synthesis in non-Small Cell Lung Cancer. Oncogene (2020) 39:2948–60. doi: 10.1038/s41388-020-1196-5 - DOI - PMC - PubMed
    1. Peebles RS, Jr. Prostaglandins in Asthma and Allergic Diseases. Pharmacol Ther (2019) 193:1–19. doi: 10.1016/j.pharmthera.2018.08.001 - DOI - PMC - PubMed
    1. Hubich AI, Sholukh MV. Biochemistry of Prostaglandins a. Biochem (Mosc) (2006) 71:229–38. doi: 10.1134/S0006297906030011 - DOI - PubMed

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