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Review
. 2022 Jun 22:9:888624.
doi: 10.3389/fmolb.2022.888624. eCollection 2022.

Non-Coding RNAs: New Dawn for Diabetes Mellitus Induced Erectile Dysfunction

Wenchao Xu  1   2 , Hongyang Jiang  1   2 , Jihong Liu  1   2 , Hao Li  1   2
Affiliations
Review

Non-Coding RNAs: New Dawn for Diabetes Mellitus Induced Erectile Dysfunction

Wenchao Xu et al. Front Mol Biosci. .

Abstract

Erectile dysfunction (ED) is a common sexual dysfunction in males, with multifactorial alterations which consist of psychological and organic. Diabetes mellitus (DM) induced erectile dysfunction (DMED) is a disconcerting and critical complication of DM, and remarkably different from non-diabetic ED. The response rate of phosphodiesterase type 5 inhibitor (PDE5i), a milestone for ED therapy, is far from satisfactory in DMED. Unfortunately, the contributing mechanisms of DMED remains vague. Hence, It is urgent to seek for novel prospective biomarkers or targets of DMED. Numerous studies have proved that non-coding RNAs (ncRNAs) play essential roles in the pathogenesis process of DM, which comprise of long non-coding RNAs (lncRNAs) and small non-coding RNAs (sncRNAs) like microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). However, the implications of ncRNAs in DMED are still understudied. This review highlights the pathophysiology of DMED, summarizes identified mechanisms of ncRNAs associated with DMED and covers the topic of perspectives for ncRNAs in DMED.

Keywords: diabetes mellitus; erectile dysfunction; lncRNA; miRNA; non-coding RNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Microscopic mechanisms underlying penile smooth muscle relaxation. Cavernous nerve and endothelial cell all can secrete NO to relax corpus cavernosum smooth muscle cells. As the smooth muscle relaxes, blood fills the lacunar spaces, resulting to compression of the subtunical venules, thereby restricting the venous outflow.
FIGURE 2
FIGURE 2
The biogenesis of miRNAs and an example of miRNA in DMED.
FIGURE 3
FIGURE 3
Therapies targeting ncRNAs.
See this image and copyright information in PMC

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