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. 1987;19(3):190-6.
doi: 10.1007/BF00252971.

Phase I study of beta-alanyl-melphalan as a potent anticancer drug

B L Tsay, L Wolfinbarger Jr

Phase I study of beta-alanyl-melphalan as a potent anticancer drug

B L Tsay et al. Cancer Chemother Pharmacol. 1987.

Abstract

The dipeptide beta-alanyl-melphalan was synthesized and tested for its potential anticancer activity. It is shown to possess considerable toxicity toward Ehrlich ascites tumor cells and 3T3 mouse embryo cells in in vitro toxicity assays and is a potent anticancer agent when used in vivo in traditional phase I chemotherapy assays. The potential role for small peptide transport mechanisms in transportation of anticancer agents is discussed.

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References

    1. Arch Biochem Biophys. 1975 Dec;171(2):637-44 - PubMed
    1. J Bacteriol. 1975 Jun;122(3):949-56 - PubMed
    1. J Bacteriol. 1973 Nov;116(2):751-6 - PubMed
    1. Farmaco Sci. 1983 Apr;38(4):205-18 - PubMed
    1. J Bacteriol. 1974 Aug;119(2):371-8 - PubMed

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